The Invention Science Fund I LLC

Elwha LLC

Washington University

Gearbox LLC

Searete LLC

Deep Science, LLC

Neurolutions, Inc.

Facetoface Biometrics, Inc.

Equility LLC

Tokitae LLC

Other

Saint Louis University

Southern Illinois University

Alcyone Lifesciences, Inc.

Seavete LLC

Eric Leuthardt

Lowell L Wood, Jr

Roderick A Hyde

Clarence T Tegreene

Muriel Y Ishikawa

Elizabeth A Sweeney

Jordin T Kare

Edward K Y Jung

Nathan P Myhrvold

Victoria Y H Wood

Robert W Lord

Mark A Malamud

Dennis James Rivet, Ii

Royce A Levien

Edward Stuart Boyden

Michael A Smith

John D Rinaldo, Jr

Robert Samuel Langer

Charles Whitmer

Richard T Lord

Chris Demetrios Karkanias

Gregory J Della Rocca

Thomas A Weaver

Jason Garms

Kristin Michele Tolle

Shawn P Firminger

Tony S Pan

Ralph G Dacey, Jr

Daniel Hawkins

Daniel B Cook

Mahalaxmi Gita Bangera

Ed Harlow

Eleanor V Goodall

Joshua L Dowling

Stephen L Malaska

Parag Jitendra Parikh

Terence Myckatyn

Joshua S Shimony

Gary L McKnight

Colin Derdeyn

Gregory Zipfel

Michael Baym

Philip Andrew Eckhoff

Erez Lieberman

Jeffrey A Bowers

Bran Ferren

W Daniel Hillis

Paul Duesterhoft

William Henry Gates, Iii

Jesse R Cheatham, Iii

Daniel W Moran

Katherine E Sharadin

Paul G Allen

Robert C Petroski

Peter L Hagelstein

Michael Schnall-Levin

Hon Wah Chin

Richard Neil Zare

Thomas J Nugent, Jr

Todd J Stewart

Eric J Horvitz

Alexander J Cohen

Douglas Christopher Burger

Craig J Mundie

Willard Harvey Wattenburg

Nicholas W Touran

John L Manferdelli

Barney Pell

Allen L Brown, Jr

Elizabeth L Schubert

Guy M Genin

William David Duncan

David Bazeley Tuckerman

Alistair K Chan

Richard Glen Ellenbogen

Abraham Snyder

Yaroslav Aleksandrovich Urzhumov

Matthew MacEwan

Lihong V Wang

Erez Lieberman Aiden

David R Smith

Desney S Tan

Paul Henry Dietz

Tom Driscoll

Lonnie J Love

Kenneth G Caldeira

Nels R Peterson

Stephen Hugh Salter

Max Nathan Mankin

John Latham

Kevin Michael Esvelt

Mark Kuiper

Peter J D'Aquanni

Robert Ryan Ragland

Donald Leo Elbert

Jared I Drinkwater

Boyd Drew Allin

Leif T Stordal

P J Anand

A method for mapping brain function of a subject includes receiving a dataset of resting state fMRI (RS-fMRI) three dimensional (3D) image frames of the subject's brain, and inputting the 3D image frames to a deep learning artificial neural network. For each voxel of each 3D image frame and for each resting state network of a plurality of resting state networks, the deep learning artificial neural network calculates a probability that the voxel belongs to the resting state network. The deep learning artificial neural network is trained beforehand using a plurality of 3D image frames including previously defined resting state networks obtained from a plurality of calibration subjects. The method includes generating one or more functional map of the plurality of resting state networks of the subject's brain using the probabilities calculated by the artificial neural network.

Methods and systems for resting state fMRI brain mapping with reduced imaging time

A biomarker predictive of a survival outcome of a brain tumor patient is disclosed. The biomarker includes a functional connectivity matrix that includes a plurality of matrix elements. Each matrix element includes a correlation of resting-state fMRI activities of a first and second region of interest from a plurality of regions of interest within the patient's brain. Computing device and systems are disclosed to transform a resting-state fMRI dataset obtained from the patient into the biomarker and to transform the biomarker into a predicted survival outcome using a machine learning model.

Systems and methods for producing a brain lesion functional MRI biomarker, predicting patient prognosis, and treatment planning

An example wearable device for placement relative to an ear includes a housing; a first extending structure; a second extending structure, the first and second extending structures are separated by an adjustable distance; a carriage coupled to the second extending structure and being at least partially disposed within the housing, the carriage being configured to move longitudinally along the housing and an adjustment mechanism configured to impart a force to cause longitudinal movement of the carriage to adjust the adjustable distance.

Adjustable ear worn apparatus

Systems, devices and methods are provided for conducting a pain management therapy session, which includes performing a BCI training session utilizing feedback to train a subject to generate defined brain signals to assist the subject in managing and/or relieving pain, and applying a stimulus to the subject, in connection with the BCI training session, at a location that is near the source of pain and/or within the nervous system pain pathway to the source of pain.

Brain computer interface based pain management therapy

Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

Methods and systems for noninvasive and localized brain liquid biopsy using focused ultrasound

Methods, devices, systems, and apparatus, including computer programs encoded on a computer storage medium, for brain-controlled body movement assistance devices. In one aspect, a device includes a brain-controlled body movement assistance device with a brain-computer interface (BCI) component adapted to be mounted to a user, a body movement assistance component operably connected to the BCI component and adapted to be worn by the user, and a feedback mechanism provided in connection with at least one of the BCI component and the body movement assistance component, the feedback mechanism being configured to output information relating to a usage session of the brain-controlled body movement assistance device.

Brain-controlled body movement assistance devices and methods

A computing device for use in a system for mapping brain activity of a subject includes a processor. The processor is programmed to select a plurality of measurements of brain activity that is representative of at least one parameter of a brain of the subject during a resting state. Moreover, the processor is programmed to compare at least one data point from each of the measurements with a corresponding data point from a previously acquired data set from at least one other subject. The processor is also programmed to produce at least one map for each of the measurements based on the comparison of the resting state data point and the corresponding previously acquired data point. The processor may also be programmed to categorize the brain activity in a plurality of networks in the brain based on the map.

System and method for task-less mapping of brain activity

Devices for recording brain activity of a subject include a first arm shaped to extend along a subject's head, the first arm having a first aperture that allows access to the subject's head. A sensor assembly of the device has multi-directional adjustability in orientation. The sensor assembly includes a shell configured for multi-directional rotation; a sleeve inside the shell; an elastic element attaching a first end of the sleeve to an interior end of the shell; and a sensor removably inserted into the sleeve, with a contact surface of the sensor facing the subject's head. The device also includes a housing that contains an energy source and operational components for the sensor assembly.

Brain signal sensing headset

The present disclosure generally relates to systems and methods for guiding surgical tools to a surgical site, and more particularly, to systems and methods for guiding a tool sheath of a delivery system to a surgical site such as a location in a subject's brain and associated surgical procedures.

Systems and methods for guiding surgical tools

A system for stimulating a sympathetic chain includes an electrode assembly that is configured to attach to a bone in proximity to a targeted portion of the sympathetic chain. The electrode assembly includes a cathode and an anode. The system also includes a power supply connected to the electrode assembly and configured to deliver power to the electrode assembly. The electrode assembly generates an electrical field between the cathode and the anode when power is delivered to the electrode assembly. The electrical field reaches the targeted portion of the sympathetic chain to provide electrical stimulation to the targeted portion of the sympathetic chain.

Systems and methods for stimulating sympathetic nervous system

Some embodiments include a method of providing security and privacy for a message sender. The method can include a messaging application determining that a messaging interface of the computing device is active and is revealing or about to reveal the electronic message. The messaging application can identify a recipient account of a messaging server system that is associated with the electronic message according to the electronic message or the messaging server system. The messaging application can then monitor a data feed from a sensor of the computing device to detect a biometric pattern that matches against a biometric profile model associated with the recipient account utilizing a biometric recognition process. In response to determining that the detected biometric pattern does not match the biometric profile model associated with the recipient account, the messaging application can activate a privacy shield to prevent content of the electronic message from being revealed.

Message sender security in messaging system

A method of using a catheter assembly for inserting in a fluid filled space in a body includes providing a main body having a first end portion and a second end portion. The first end portion is positioned within the fluid filled space. The second end portion is adjusted to extend outwardly from the fluid filled space when the first end portion is positioned within the fluid filled space. A catheter tip is connected to the second end portion of the main body. The catheter tip includes a housing having a cavity defined therein and a rotating element positioned within the fluid filled space. The rotating element is rotated within the cavity of the housing to impart movement of the first end portion of the main body within the fluid filled space.

Catheter tip for a catheter assembly

A target location for a therapeutic intervention is determined in a subject with a neurological disorder. The target location is selected within at least one resting state network (RSN) map according to a predetermined criterion for the neurological disorder. The at least one RSN map includes a plurality of functional voxels within a brain of the subject, and each functional voxel of the plurality of functional voxels is associated with a probability of membership in an RSN. Instructions are transmitted to a treatment system that cause operation to be performed on the selected target location.

Supervised classifier for optimizing target for neuromodulation, implant localization, and ablation

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St. Louis, MO, United States of America

Eric Leuthardt