Prolynx LLC

University of California

Eric L Schneider

Gary W Ashley

Brian R Hearn

Daniel V Santi

Charles S Craik

Shaun Fontaine

Gary Ashley

Provided are β-eliminative linkers suitable for the conjugation of small molecule, peptide, and protein and compounds comprising the linkers.

Conjugation linkers

Conjugates of carriers and hydrogels for controlling the biological half-life of somatostatin and its analogs are disclosed.

Conjugates of somatostatin analogues

Conjugates of SN-38 that provide optimal drug release rates and minimize the formation of the corresponding glucuronate are described. The conjugates release SN-38 from a polyethylene glycol through a &#x3b2;-elimination mechanism.

Slow-release conjugates of SN-38

The disclosure relates to protease-binding agent specific for a protease. The agent may be an antibody capable of specifically binding and inhibiting a protease, such as a P1-Arg-specific protease. The disclosure also provides methods of producing, and compositions comprising the subject agent. Methods and kits related to the protease-binding agent find use in protection against, detection, diagnosing, treating cancer and infections due to pathogens containing active proteases.

Growing community of inventors

Oakland, CA, United States of America

Eric L Schneider