Treventis Corporation

Eric Joy

Sultan Darvesh

Earl Martin

Ian Macdonald

Ian Pottie

Compounds useful for the early diagnosis of malignant tumors, multiple sclerosis, and especially Alzheimer's Disease and related dementias; especially compounds of Formula (I) wherein Ris selected from the group consisting of hydrogen, cyano, fluoro, iodo, alkyl, and aryl; Ris selected from the group consisting of hydrogen, alkyl, and aryl; X is selected from the group consisting of CH, CHO, oxygen, OCH, CHS, SCH, NH, N-alkyl, and N-aryl; Y is an optional spacer group, absent or selected from the group consisting of oxygen, sulfur, NH, N-alkyl, and N-aryl; and Z is selected from the group consisting of alkyl substituted with cyano, fluoro, or iodo and aryl substituted with cyano, fluoro, or iodo. In a preferred embodiment, Rand Rare hydrogen, X is CHO, Y is absent, and Z is phenyl substituted with fluoro, cyano, or iodo. In some embodiments, Z is more specificallyF-phenyl orI-phenyl orI-phenyl. Other compounds are also provided. 

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Lower Sackville, Canada

Eric Joy