Transgene S.a.

Other

Pasteur Merieux Serums Et Vaccins

Eric Jacobs

Anthony Bernard Schryvers

Nathalie Silvestre

Marie-Aline Bloch

Bernadette Bouchon-Theisen

Michel C Jolivet

Bruno Mougin

Mich&egrave;le LeGrain

Odette Bissardon

Michele Legrain

Veronique Mazarin

Ernst Schweinbryber

Nathalie Sylvestre

V&eacute;ronique Mazarin

The present invention provides novel peptides of specified sequence and their use as a signal peptide or a membrane-anchoring peptide. It also relates to chimeric polypeptide comprising one or more such peptides and a polypeptide of interest as well as nucleic acid molecules, vectors, infections vital particles and host cells encoding such peptides and chimeric polypeptides. The present invention also relates to a pharmaceutical composition comprising such elements and a pharmaceutically acceptable vehicle. The present invention also provides a method for recumbently producing a polypeptide using such peptides, especially for directing expression of a polypeptide of interest extracellularly or anchored at the surface of the plasma membrane.

Signaling peptides

The present invention provides a reagent for the detection or monitoring of a infection, which includes as a reactive substance a truncated P30 protein in which all of the hydrophobic C-terminal region of the native protein starting with the amino acid positioned after the amino acid 299 (SEQ ID NO: 1) has been deleted and all of the region of the native protein having the sequence starting with amino acid 31 and ending with the amino acid 299 (SEQ ID NO: 1) is contained. The present invention further describes methods of screening for anti-Toxoplasma antibodies in a biological sample.

Cassette for expressing a toxoplasma gondii P30 protein

A transposition assembly for the transfer of a DNA fragment of interest into the ribosomal nuclear DNA of an eukaryotic cell. An insertion means, an eukaryotic cell and a pharmaceutical composition comprising said transposition assembly, as well as a method for the in vitro transfer of said DNA fragment, are also disclosed.

Transposition assembly for gene transfer in eukaryotes

The subject of the present invention is a DNA fragment which encodes a protein capable of being recognised by an antiserum against the transferrin receptor of the strain IM2394 or IM2169 of,as well as a process for producing the said protein by a recombinant route. By way of example, such a DNA fragment encodes the tbp1 subunit of the strain IM2394 or IM2169 or the tbp2 subunit of the strain IM2394 or IM2169.

Transferrin receptor subunit proteins of Neisseria meningitidis

The subject of the present invention is a DNA fragment which encodes a protein capable of being recognised by an antiserum against the transferrin receptor of the strain IM2394 or IM2169 of N. meningitidis as well as a process for producing the said protein by a recombinant route. By way of example, such a DNA fragment encodes the tbp1 subunit of the strain IM2394 or IM2169 or the tbp2 subunit of the strain IM2394 or IM2169.

Compositions comprising the Tbp2 subunit of the transferrin receptor of

Combined use of two expression cassettes for the production of a protein

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Dorlisheim, France

Eric Jacobs