University of Washington

Visiongate, Inc.

Magic Leap, Inc.

Other

Qatar University Al Tarfa

Eric J Seibel

Mark Fauver

Richard Stephen Johnston

Brian T Schowengerdt

Charles David Melville

Per G Reinhall

Timothy D Soper

Alan C Nelson

J Richard Rahn

Leonard Y Nelson

Cameron M Lee

Thomas Adrian Furness, Iii

Quinn Y J Smithwick

Robb W Glenny

Chris Brown

Steven L Brunton

Chen Gong

Mark E Fauver

Krzysztof Palczewski

Ivan L Yeoh

Bryan S Sires

Matthew J Kundrat

Yoshikazu Imanishi

Qin Miao

Ryan Lee Coe

Janet Crossman-Bosworth

Steven Maxwell Seitz

Michael G Meyer

Roger H Johnson

Xiumei Liu

Thomas Neumann

Wei-Chih Wang

Thomas A Reh

Laura Cristina Trutoiu

Xingde Li

Winyu Chinthammit

John A Myers

Michael B Kimmey

Jeffrey S Mclean

Brandon Tuttle

Robert E Carroll

Wei-Chi Wang

Blake Miller

Donald E Parker

Jerrold D Prothero

Woon Jong Yoon

Been-Lirn Henry Duh

Matthew R Burkhardt

Chenying Yang

Saniel D Lim

Liang Zhang

Nils Benjamin Erichson

Ronnie Das

Joel Berg

Jasmine Graham

Manuja Sharma

Zheng Xu

Christopher W Burfeind

Yuanzheng Gong

Yaxuan Zhou

Thu-mai Nguyen

Richard J Rahn

The present disclosure provides a fluidic device including a first inlet, an outlet, and a channel positioned between the first inlet and the outlet. The channel is in fluid communication with the first inlet and the outlet. The fluidic device further includes a second inlet positioned between the first inlet and the outlet. The second inlet is in fluid communication with the channel. The fluidic device further includes a pump in fluid communication with the second inlet. The pump is configured to provide a first volume of pulsatile flow to the channel. The first volume of pulsatile flow is greater than about 50 μL per pulse.

System, device, and method for biopsy removal from needles into a fluidic device

Techniques for tracking eye movement in an augmented reality system identify a plurality of base images of an object or a portion thereof. A search image may be generated based at least in part upon at least some of the plurality of base images. A deep learning result may be generated at least by performing a deep learning process on a base image using a neural network in a deep learning mode. A captured image may be localized at least by performing an image registration process on the captured image and the search image using a Kalman filter model and the deep learning result.

Eye tracking in near-eye displays

A monitoring system includes a light source, a light detector, a processor, and a non-transitory computer readable medium storing instructions that, when executed by the processor, cause the monitoring system to perform functions. The functions include illuminating, via the light source, a biological sample that is within a container while a fixation process is performed on the biological sample. The functions also include determining, via the light detector, that an optical transmittance of the biological sample satisfies a condition. The functions also include ceasing the fixation process in response to determining that the optical transmittance of the biological sample satisfies the condition.

Optical fixation monitor

Systems and methods for accurate optical pH sensing of biofilms are disclosed. In one embodiment, a method of measuring an extracellular pH level using multiple wavelengths emitted by a fluorescent substance includes: exciting the fluorescent substance at an excitation wavelength; measuring a first fluorescence intensity at a first wavelength of a fluorescence emission; and measuring a second fluorescence intensity at a second wavelength of the fluorescence emission. The second wavelength is different from the first wavelength. The method also includes determining the extracellular pH level based on the first fluorescence intensity at the first wavelength and the second fluorescence intensity at the second wavelength.

Systems and methods for accurate optical pH sensing of biofilms

A retina image template matching method is based on the registration and comparison between the images captured with portable low-cost fundus cameras (e.g., a consumer grade camera typically incorporated into a smartphone or tablet computer) and a baseline image. The method solves the challenges posed by registering small and low-quality retinal template images captured with such cameras. Our method combines dimension reduction methods with a mutual information (MI) based image registration technique. In particular, principle components analysis (PCA) and optionally block PCA are used as a dimension reduction method to localize the template image coarsely to the baseline image, then the resulting displacement parameters are used to initialize the MI metric optimization for registration of the template image with the closest region of the baseline image.

System and method for retina template matching in teleophthalmology

A system for the optical measurement of pH includes a light emitter to emit an excitation light, and a detector coupled to receive florescence light produced by a compound in a mouth of a patient in response to the excitation light. A controller is coupled to the detector, and the controller includes logic that when executed by the controller, causes the system to perform operations. The operations may include emitting the excitation light from the light emitter; measuring an intensity of the florescence light emitted from a surface of individual teeth in a plurality of teeth in the mouth; and determining, based on the intensity of the florescence light, one or more locations on the individual teeth likely to develop demineralization.

System and method for ranking bacterial activity leading to tooth and gum disease

In some embodiments, an apparatus, system, and method for activating a low-adhesion state of a thermal-sensitive tape is described. An example apparatus embodiment includes a light source and a temperature sensor. The light source is configured to illuminate a target area of the thermal-sensitive tape with a first spectrum of electromagnetic radiation to provide heating of the target area. The first spectrum including a first wavelength outside of a visible spectrum. The temperature sensor is configured to detect a second spectrum of electromagnetic radiation to approximate a temperature of the target area. The second spectrum includes a second wavelength different than the first wavelength.

Apparatus, system, and method for activating a low-adhesion state of thermal-sensitive tape

An example fluidic device includes an elastic tube, a first actuator coupled to an outer surface of the elastic tube between a first end and a second end of the elastic tube, and a second actuator coupled to the outer surface of the elastic tube between the first actuator and the second end of the elastic tube. The first actuator and the second actuator are configured to move apart from one another to transition a portion of the elastic tube positioned between the first actuator and the second actuator from a first condition to a second condition. A diameter of the elastic tube is greater in the first condition than in the second condition. The fluidic device also includes one or more rotatable components coupled to the first actuator and the second actuator which are configured to rotate the portion of the elastic tube positioned between the first actuator and the second actuator.

Biopsy sample manipulation and imaging system and methods for use

A photosensitive medical tape includes a backing layer that is at least partially transparent to a first spectrum of electromagnetic radiation. The photosensitive medical tape also includes a coupling layer disposed on a first side of the backing layer to provide adhesion of the photosensitive medical tape to the human skin. The photosensitive medical tape is disposed to absorb a second spectrum of electromagnetic radiation to decrease a strength of the adhesion provided by the coupling layer. The photosensitive medical tape is also flexible.

Photosensitive medical tape

Methods and systems for acquiring and/or projecting images from and/or to a target area are provided. Such a method or system can include an optical fiber assembly which may be driven to scan the target area in a scan pattern. The optical fiber assembly may provide multiple effective light sources (e.g., via a plurality of optical fibers) that are axially staggered with respect to an optical system located between the optical fiber and the target area. The optical system may be operable to focus and/or redirect the light from the multiple light sources onto separate focal planes. A composite image may be generated based on light reflected from and/or projected onto the separate focal planes. The composite image may have an extended depth of focus or field spanning over a distance between the separate focal planes while maintaining or improving image resolution.

Extended depth of focus for high-resolution optical image scanning

Image projection devices, high-speed fiber scanned displays and related methods for projecting an image onto a surface and interfacing with the projected image are provided. A method for projecting one or more images and obtaining feedback with an optical input-output assembly is provided. The input-output assembly comprising a light-scanning optical fiber and a sensor. The method includes generating a sequence of light in response to one or more image representations and a scan pattern of the optical fiber, articulating the optical fiber in the scan pattern, projecting the sequence of light from the articulated optical fiber, and generating a feedback signal with the sensor in response to reflections of the sequence of light.

Scanning laser projection display for small handheld devices

Methods and systems for detecting early stage dental caries and decays are provided. In particular, in an embodiment, laser-induced autofluorescence (AF) from multiple excitation wavelengths is obtained and analyzed. Endogenous fluorophores residing in the enamel naturally fluoresce when illuminated by wavelengths ranging from ultraviolet into the visible spectrum. The relative intensities of the AF emission changes between different excitation wavelengths when the enamel changes from healthy to demineralized. By taking a ratio of AF emission spectra integrals between different excitation wavelengths, a standard is created wherein changes in AF ratios within a tooth are quantified and serve as indicators of early stage enamel demineralization. The techniques described herein may be used in conjunction with a scanning fiber endoscope (SFE) to provide a reliable, safe and low-cost means for identifying dental caries or decays.

Dental demineralization detection, methods and systems

An example fluidic device may include a plurality of channels including one or more curved channels having a channel input and a channel output. Each of the one or more curved channels may have a substantially circular cross-section. The fluidic device may also include an input interface between the channel input of the one or more curved channels and an exterior of the fluidic device. The input interface may be configured to receive a biological tissue sample. The fluidic device may also include an output interface between the channel output of the one or more curved channels and the exterior of the fluidic device.

Fluidic device and methods of use for processing tissue for pathology

An imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images is disclosed. One embodiment includes a light source and an imaging system having an adjustable focal position, which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also disclosed is a system and method for preparing a specimen for optical microscopy. One embodiment includes fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.

Optical projection tomography microscopy (OPTM) for large specimen sizes

Growing community of inventors

Seattle, WA, United States of America

Eric J Seibel