Histogenics Corporation

Other

Organogenesis, Inc.

Medlogic Global Corporation

Ocugen, Inc.

Gel Sciences, Inc.

Eric J Roos

Laurence J B Tarrant

Robert Lane Smith

Sonya Shortkroff

Hans P I Claesson

Matthew E Schiller

Eyal S Ron

Leon M Wilkins

Hans Peter Ingemar Claesson

Christopher O'Reilly

Ruben Chevere

Anne Staples

Michal Orkisz

A method for use of a double-structured tissue implant or a secondary scaffold stand-alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand-alone secondary scaffold implant or unit for treatment of tissue defects.

Method for use of a double-structured tissue implant for treatment of tissue

Method for use of a double-structured tissue implant for treatment of tissue defects

A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects.

A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit.

A bioreactor has a base for defining a well, a dish with a membrane suspended in the base, and a lid with gas permeable membranes and self-sealing ports.

Culture dish and bioreactor system

System for delivery of a biologically active substance into an environment. First and second chambers are separated by a moveable partition. The first chamber includes a polymer gel network which undergoes a volume change in response to an environmental condition such as pH. The first compartment includes a screen or membrane for confining the polymer gel network while allowing communication with fluid in an environment. The second compartment contains a biologically active compound or drug which is delivered to the environment through an orifice in the second compartment. Upon the occurrence of the triggering environmental condition, the polymer gel network undergoes a volume change which moves the moveable partition expelling the drug through the orifice. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met.

Chemo-mechanical expansion delivery system

Polymer gel networks loaded with biologically active solutes in a manner that solute activity is maintained and protected from thermal and/or chemical degradation while in the gel network are provided. The invention also provides for effects of modulating parameters for loading safe responsive gel networks using loading solutions containing phase separating polymers.

Loading of biologically active solutes into polymer gels

Apparatus and method for delivering a biologically active compound into

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Grafton, MA, United States of America

Eric J Roos