Ventana Medical Systems, Inc.

Vital Signs, Inc.

Enginivity, LLC

Eric J May

Jerome W Kosmeder, Ii

Brian Daniel Kelly

Christopher Bieniarz

Michael Otter

Larry E Morrison

Benjamin C Stevens

Nathan Crum

Taylor J Shingler

Joseph M Jakubowski

David Ellsworth Cassidy

Michael Patrick Farrell

Noemi Sebastiao

Wenjun Zhang

Adrian E Murillo

Lei Tang

Antony Hubbard

Tsu-Shuen Tsao

James Grille

Pamela Wirth

Jerome W Kosmeder

Jerome Kosmeder

Richard Bucchianeri

Alexandra Dea Nagy

Richard Buccianeri

Alexandra Nagy

Ii Jerome W Kosmeder

D Brian Kelly

W Jerome Kosmeder

Automated systems to make target compounds from slide stainer waste streams inactive utilizing advanced oxidation processes are described herein. Advanced oxidation processes are promoted by UV irradiation and further accelerated by use of radical initiators, such as hydrogen peroxide. The automated systems further include mechanisms for segregating components of the waste streams.

Passive, gravity-driven system for treatment of an effluent in a diagnostic system

Disclosed embodiments concern a composition comprising DAB chromogen, and/or derivative thereof, a stabilizer, and polymer capable of preventing or reducing DAB precipitation relative to a composition that does not comprise the polymer. Also disclosed herein is a method for using the disclosed composition and embodiments of a kit.

Polymer stabilization of chromogen solutions

The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

Multiplexed immunohistochemistry using recombinant antibodies with epitope tags

Disclosed are compositions and methods for inactivating one or more enzymes in a biological sample.

Compositions and methods for simultaneous inactivation of alkaline phosphatase and peroxidase enzymes during automated multiplex tissue staining assays

This disclosure relates to compositions that enhance the deposition of detectable moieties on tissue samples, methods utilizing these compositions and kits including these compositions. The compositions include a deposition enhancer having a formula where R, R, R, and Rare independently selected from aliphatic, aryl, halogen, a heteroatom-containing moiety, and hydrogen; Rand/or Rcan be bound to Rto form a fused, aromatic ring system; Ris selected from a heteroatom-containing moiety; A is selected from, a carbon atom, a heteroatom, other than sulfur, and any combination thereof; n is 1-5, an enzyme, a specific binding moiety and a detectable moiety.

Enhanced deposition of chromogens utilizing pyrimidine analogs

Embodiments of a composition for stabilizing fluorescent signal of nanoparticles and methods for its use are disclosed. In some embodiments, the composition has a pH from 7 to 10 and includes borate, protein and/or protein hydrolysate, an amine, a preservative, and a nonionic surfactant. In particular embodiments, the amine is an N-ethanol substituted amine, such as ethanolamine, diethanolamine, triethanolamine, N-methyldiethanolamine, N,N-dimethylethanolamine, or a combination thereof. In some embodiments, a fluorescent particle solution, such as a quantum dot solution or quantum dot conjugate solution, is diluted in the composition and stored at 4&#xb0; C. In certain embodiments, the fluorescence intensity of the diluted fluorescent particle remains substantially the same when stored at 4&#xb0; C. for at least one month or at least three months. In particular embodiments, a diluted quantum dot conjugate is used to detect a hybridized probe or a protein antigen.

Composition and method for stabilizing fluorescent particles

Enhanced deposition of chromogens

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Chandler, AZ, United States of America

Eric J May