Merck Sharp + Dohme Corp.

Eric J Choi

John S Wai

Peter D Williams

Shankar Venkatraman

Wayne J Thompson

Dai-Shi Su

Mark W Embrey

Peter Emmanuel Maligres

Zhiguo Jake Song

Gregory L Beutner

Jeremy Peter Scott

Thorsten E Fisher

Tao Pei

Laura Marie Artino

Jingjun Yin

David C Dubost

Neil A Strotman

Richard C A Isaacs

Michael Shevlin

Dietrich P Steinhuebel

Clinton Scott Shultz

Richard G Ball

Matthew L Maddess

Robert M Wenslow, Jr

Neil Campbell

Sarah L Trice

Juan D Arredondo

Matthew Maddess

The present invention relates to different forms of a HCV inhibitory compound.

Crystal forms of a HCV protease inhibitor

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein X, X, Y, R, R, Rand Rare defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Processes for making compounds of Formula I and intermediates thereof are also described.

HIV integrase inhibitors

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Libertyville, IL, United States of America

Eric J Choi