Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk

Commer S.r.l.

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Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek

Nederlandse Centrale Organisatie Voor Toegepast Natuurwelenschappelyk

Eric J Bulten

Francois Verbeek

Klaas Timmer

Jan Berg

Harmen A Meinena

Gerrit J Van Der Kerk

Antonius M Liebregts

Jan W Van Den Hurk

Antje Kaars Sijpesteijn

Hendrik A Budding

Method for the preparation of catalysts on support materials, such as strontiumtitanate, which serve for the hydrogenation of unsaturated organic compounds such as alkenes, alkynes and aromates, which catalysts consist of rhodium-metal on support, obtained by applying rhodiumcarbonyl-clusters to a support in an inert atmosphere and then pyrolyzing them at a relatively low temperature of for instance 150.degree. C. The material, thus applied to the support is activated by means of a reaction with oxygen, preferably between 0.degree. and 150.degree. C.

Method for the preparation and application of rhodium catalysts for the

Tin compounds, a process for the preparation thereof, a process for the preparation of a medicine using such a tin compound for the treatment of malignant tumors in mice as well as the shaped medicine thus obtained. This invention relates to novel tin compounds, a pharmaceutical composition using the novel compounds and methods for treating cancer using the pharmaceutical composition.

Tin compounds

Germanium compounds, a process for the preparation thereof, a process for the preparation of a medicine using such a germanium compound for the treatment of cancer as well as the shaped medicine thus obtained. This invention relates to novel germanium compounds, a pharmaceutical composition using the novel compounds and methods for treating cancer using the pharmaceutical composition.

Germanium compounds

This invention relates to novel-platinum (IV)-diamine complexes, a pharmaceutical composition using the novel complexes and methods of treating malignant tumors in mice using the pharmaceutical composition.

Platinum (IV)-diamine complexes, a process for the preparation of

Platinum diamine complexes of the general formulae ##STR1## wherein R.sub.1 and R.sub.2 independently from each other are a hydrogen atom or a substituted or unsubstituted alkyl, cyclo-alkyl, aryl or aralkyl group, while R.sub.1 and R.sub.2 may be together a substituted or unsubstituted cyclo-alkyl group, R.sub.3 and R.sub.4 independently of each other are a hydrogen atom or a substituted or unsubstituted alkyl, aryl or aralkyl group and X is a chlorine, bromine or iodine atom, a sulphate radical, a substituted or unsubstituted carboxylate rest like an acetate or substituted acetate radical, an oxalate, malonate, hydroxymalonate or otherwise substituted malonate group or a carboxylate group, the group Y, independently from X is a chlorine, bromine or iodine atom, a hydroxyl group, a nitrate group of a carboxylate group have been found to exhibit antitumor activity together with little or none kidney toxicity and are thus of interest as a medicament. Processes for the preparation of the platinum complexes are described and exemplified.

Platinum-diamine complexes, a process for the preparation thereof, a

Platinum(IV)-diamine-complexes, a process for the preparation thereof, a process for the preparation of a medicine using such a platinum(IV)-diamine-complex for the treatment of malignant tumors in mice as well as the shaped medicine thus obtained. This invention relates to novel platinum-diamine complexes, a pharmaceutical composition using the novel complexes and methods of treating malignant tumors in mice using the pharmaceutical composition.

Platinum(IV)-diamine complexes, a process for the preparation thereof, a

Antifungal and/or antibacterial organotin compounds characterized by the formula

Antifungal and/or antibacterial organotin compounds, and use

In the process for the preparation of alkyl tin halides by means of direct conversion of tin with aliphatic halides, the alkyl halide is fed in such a way gradually to the gas space over the further reaction components that there is an overpressure of no more than a few cms of mercury. The reaction is carried out in the presence of a liquid acid amide in quantities of 0.65 to 2.3 mol per gramatom of tin and in the presence of catalytic amounts of iodine and/or iodide at raised temperatures. The reaction is promoted under the influence of ultraviolet irradiation and by the addition of a catalyst of the type promoting free radial initiation reactions. SU

Method for the preparation of alkyl tin halides

The preparation of alkyl tin halides is carried out by direct conversion of a gaseous lower aliphatic halide with a stannous halide in the presence of a nitrogenous solvent of the acid amide type at substantially atmospheric pressure. The acid amide solvent is present in quantities of approximately 1-4 mol per mol stannous halide. This reaction proceeds without the production of any trialkyl tin compounds as by-products.

The addition of organo germanium compounds having the formula

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Bilthoven, Netherlands

Eric J Bulten