Syntex (u.s.a.) Inc.

Pfizer Corporation

Pharmacia Corporation

Syntex Pharmaceuticals International Limited

Eric J Benjamin

Brian H Vickery

Lynda M Sanders

Shabbir T Anik

Cherng-chyi Fu

Ya-Yun T Lin

Gary C Visor

Lih-Yang Lin

Maryann O Lee

Pharmaceutical compositions of biologically active polypeptides in powder form suitable for nasal administration, comprising a therapeutically effective amount of a biologically active polypeptide and a water-soluble polysaccharide.

Intranasal administration of polypeptides in powdered form

Intranasal administration of LHRH polypeptides in powdered form

A non-stinging aqueous anti-inflammatory steroid formulation suitable for intranasal administration comprises: an anti-inflammatory steroid in an amount between about 0.01% and about 0.05% (w/v); propylene glycol in an amount between about 2% and about 10% (w/v); PEG 400 in an amount between about 10% and about 25% (w/v); polysorbate 20 in an amount between about 1% and about 4% (w/v); an effective amount of a preservative; an effective amount of a stabilizer; an effective amount of an antioxidant; water; and pH buffering agent sufficient to adjust the pH of the resulting solution to between about 3.5 and about 7.

Aqueous steroid formulations for nasal administration

This invention is directed to a formulation of cardiotonic phosphodiesterase inhibitors with a water-soluble vitamin, comprising a lyophilization step performed on a solution of the complex in an aqueous/organic solvent system. The formulation results in a complex that has been found to have enhanced solubility (over the compound alone) in a parenterally or orally acceptable solvent, and the lyophilization process yields a product with superior stability permitting an extended shelf life.

Cardiotonic phosphodiesterase inhibitors complexed with water soluble

Pharmaceutically acceptable acid addition salts of sulfur containing antimicrobial 1-substituted imidazole compounds can be stabilized in talc-based powders by the addition of a basic metal salt of an inorganic or organic acid.

Stabilization of 1-substituted imidazole derivatives in talc

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Dublin, OH, United States of America

Eric J Benjamin