Centre National De La Recherche Scientifique

Cnrs and Fabrice Duprat

Eric Honore

Michel Lazdunski

Michel Fink

Florian Lesage

Fabrice Duprat

Georges Romey

Amanda J Patel

Francois Maingret

A purified protein including a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of channels in drug screening.

Mechanosensitive mammalian potassium channel activatable by polyunsaturated fatty acids

Human and mouse TREK-1 potassium transport proteins are disclosed as well a method for using potassium transport proteins for identifying substances having anesthetic properties, such as producing a safe, reversible state of unconsciousness with concurrent amnesia and analgesia in a mammal upon inhalation, in a method comprising (a) contacting the test substance with a mammalian potassium transport protein, wherein said potassium transport protein exhibits outward-going potassium rectification; and (b) determining the potassium transport activity of the potassium transport protein, wherein an activation of potassium transport is indicative of the test substance having anesthetic properties.

Method for the identification of anesthetics

A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of such channels in drug screening.

Method for screening substances capable of modulating the activity of a TRAAK potassium channel

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Juan les Pins, France

Eric Honore