Pastoral Greenhouse Gas Research Limited

North Carolina State University

Pastoral Greenhouse Research Limited

Eric Heinz Altermann

Todd Robert Klaenhammer

Rodolphe Barrangou

Graeme Trevor Attwood

William John Kelly

Sinead Christine Leahy

Zhanhao Kong

Dong Li

Robert Starr Ronimus

Petrus Hendricus Janssen

Debjit Dey

Carrie Sang

Scott A Ferguson

Carl Yeoman

Duncan McMillan

Sharla McTavish

Diana Pacheco

Suzanne Lambie

Gregory Cook

W Michael Russell

Andrea Azcarate-Peril

B Logan Buck

William Michael Russell

Linley Rose Schofield

Catherine Mary Tootill

Christina Diane Moon

Duncan Mcmillan

Sharla Mctavish

The invention encompasses components from microbial cells which are useful for antibody production, including peptides, polypeptides comprising these peptides, polynucleotides which encode these peptides or polypeptides, and antibodies directed to these peptides, polypeptides, or polynucleotides. The invention also encompasses to expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further encompasses methods and compositions, especially vaccine compositions, for detecting, targeting, and inhibiting microbial cells, especially methanogen cells, using one or more of the disclosed peptides, polypeptides, polynucleotides, antibodies, expression vectors, and host cells.

Vaccines and vaccine components for inhibition of microbial cells

The present invention includes the complete genome sequence for the methanogen,-, including polynucleotides which encodepolypeptides or peptides, as well as polynucleotides from non-coding regions. Also included are the encodedpolypeptides and peptides, and antibodies directed to these peptides or polypeptides, in addition to expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further includes methods and compositions for detecting, targeting, and inhibiting microbial cells, especially methanogen cells such ascells, using one or more of the disclosed peptides, polypeptides, polynucleotides, antibodies, expression vectors, and host cells.

Complete genome sequence of the methanogen

The present invention includes the complete genome sequence for the methanogen,-, including polynucleotides which encodepolypeptides or peptides, as well as polynucleotides from non-coding regions. Also included are the encodedpolypeptides and peptides, and antibodies directed to these peptides or polypeptides, in addition to expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further includes methods and compositions for detecting, targeting, and inhibiting microbial cells, especially methanogen cells such ascells, using one or more of the disclosed peptides, polypeptides, polynu-cleotides, antibodies, expression vectors, and host cells.

The present invention includes the complete genome sequence for the methanogen,, including polynucleotides which encodepolypeptides or peptides, as well as polynucleotides from non-coding regions. Also included are the encodedpolypeptides and peptides, and antibodies directed to these peptides or polypeptides, in addition to expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further includes methods and compositions for detecting, targeting, and inhibiting microbial cells, especially methanogen cells such ascells, using one or more of the disclosed peptides, polypeptides, polynucleotides, antibodies, expression vectors, and host cells.

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The invention encompasses phage &#x3c6;mru including phage induction, phage particles, and the phage genome. Also encompassed are phage polypeptides, as well as polynucleotides which encode these polypeptides, expression vectors comprising these polynucleotides, and host cells comprising these vectors. The invention further encompasses compositions and methods for detecting, targeting, permeabilising, and inhibiting microbial cells, especially methanogen cells, using the disclosed phage, polypeptides, polynucleotides, expression vectors, or host cells.

Phage &#x3c6;mru polynucleotides and polypeptides and uses thereof

Signal peptides and polypeptides from, a methanogenic archaea present in ruminants. Methods of using these peptides to permeabilise microbial cells, particularlystrain M1(DSM 1093).

Cell-permeabilising peptides and polypeptides for microbial cells

NCFM nucleic acid molecules, polypeptides, fragments and variants thereof are provided in the current invention. In addition, fusion proteins, antigenic peptides, and antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells comprising the expression vectors. Methods for producing the polypeptides of the invention and methods for their use are further provided.

Protease-like nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, protease-like fusion proteins, antigenic peptides, and anti-protease-like antibodies are encompassed. The invention also provides vectors containing a nucleic acid molecule of the invention and cells into which the vectors have been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.

Stress-related nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, stress-related fusion proteins, antigenic peptides, and anti-stress-related antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells into which the expression vectors have been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.

Nucleic acid encoding two-component sensing and regulatory proteins, antimicrobial proteins and uses therefor

Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface and secreted fusion proteins, antigenic peptides, and anti-cell wall, cell surface and secreted antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides of the invention and methods for their use are further disclosed.

Growing community of inventors

Palmerston North, New Zealand

Eric Heinz Altermann