The University of New Mexico

University of Florida Research Foundation Inc

Eric H Hill

David G Whitten

Kirk S Schanze

Thomas S Corbitt

Ying Wang

Harry Craig Pappas

Linnea K Ista

Eunkyung Ji

Dimitri Dascier

Motokatsu Ogawa

Patrick L Donabedian

Kiran Bhaskar

Yun Huang

Yue Zhang

Eva Yung Hua Chi

Arjun Thapa

Zhijun Zhou

Yanli Tang

Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

P-phenylene ethynylene compounds as bioactive and detection agents

The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.

Structure, synthesis, and applications for poly (phenylene) ethynylenes (PPEs)

Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure &#x2014;R&#x2014;Y&#x2014;R&#x2014;Z&#x2014;. At each occurrence, Ris independently chosen from 1,4-bonded phenylene substituted by &#x2014;X&#x2014;R-Rj times and 2,5-bonded thiophene substituted by &#x2014;X&#x2014;R-Rj times. At each occurrence, Y is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. At each occurrence, Ris independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. The variables j, R, and Rare as defined herein.

Conjugated polyelectrolytes and methods of using the same

Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethynylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and antifungal activity.

Structure, synthesis, and applications for oligo phenylene ethynylenes (OPEs)

The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.

Charged singlet-oxygen sensitizers and oppositely-charged surfactants

Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure &#x2014;R&#x2014;Y&#x2014;R&#x2014;Z&#x2014;. At each occurrence, Ris independently chosen from 1,4-bonded phenylene substituted by &#x2014;X&#x2014;R&#x2014;Rj times and 2,5-bonded thiophene substituted by &#x2014;X&#x2014;R&#x2014;Rj times. At each occurrence, Y is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. At each occurrence, Ris independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. The variables j, R, and Rare as defined herein.

Growing community of inventors

Donostia, Spain

Eric H Hill