Wisconsin Alumni Research Foundation

Eric G Schmuck

Kurt W Saupe

John A Kink

Peiman Hematti

Amish Naresh Raval

Amish Raval

Sushmita Roy

Tianhua Zhou

Amish N Raval

The disclosure generally relates to methods, cells, and compositions for preparing cardiac extracellular matrix. In particular, provided herein are methods for preparing a cardiac extracellular matrix using SUSD2 High fibroblasts and SUSD2 High myofibroblasts.

Cardiac fibroblast derived extracellular matrix

The invention relates to an ex vivo generated population of tissue-specific anti-inflammatory macrophages and methods of making and using such macrophages.

Generation of therapeutic cells using extracellular components of target organs

A bioscaffold made from an isolated cardiac fibroblast-derived 3-dimensional extracellular matrix (ECM) is disclosed. The bioscaffold can be used as an epicardial patch for the delivery of therapeutic cells into myocardial tissue. Methods of making the 3-dimensional extracellular matrix using cultured cardiac fibroblasts are also disclosed.

3-dimensional cardiac fibroblast derived extracellular matrix

3-Dimensional cardiac fibroblast derived extracellular matrix

Growing community of inventors

DeForest, WI, United States of America

Eric G Schmuck