Cardiac Pacemakers, Inc.

Cvrx, Inc.

Eric G Lovett

Jeffrey E Stahmann

Robert J Sweeney

Adam W Cates

Bruce H KenKnight

Jaeho Kim

Joseph M Bocek

Dimitrios Georgakopoulos

Brian D Soltis

Paul A Pignato

Loren Murney

Scott Thomas Mazar

Yatheendhar D Manicka

Julie A Thompson

William Hsu

John Charles Stroebel

Apurv Ullas Kamath

Darrell Orvin Wagner

Imad Libbus

Quan Ni

John D Hatlestad

Robert S Kieval

Rodney W Salo

Jesse W Hartley

Kent Lee

Nadim Yared

Kip Ludwig

Russell E Anderson

Steve Check

Surekha Palreddy

Mark Schwartz

Mike Favet

Janice Jenkins

Bruce Alan Tockman

Yongxing Zhang

Douglas J Lang

Yunlong Zhang

Alok S Sathaye

Shelley Marie Cazares

Amir J Tehrani

Yayun Lin

Alejandro Covalin

Joseph Walker

Guy Alvarez

Dimitrios Gerogakopoulos

Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. An implantable baroreflex activation system includes a control system having an implantable housing, an electrical lead, attachable to the control system, and an electrode structure. The electrode structure is near one end of the electrical lead, and includes a monopolar electrode, a backing material having an effective surface area larger than the electrode, and a releasable pivotable interface to mate with an implant tool. The electrode is configured for implantation on an outer surface of a blood vessel and the control system is programmed to deliver a baroreflex therapy via the monopolar electrode to a baroreceptor within a wall of the blood vessel.

Implant tool and improved electrode design for minimally invasive procedure

Devices and methods of use are described for identification, treatment, and/or management of heart failure and/or associated conditions. An exemplary device may include a first fluid status monitoring circuit configured to monitor a first fluid status indicator of a pulmonary fluid status associated with pulmonary edema, a second fluid status monitoring circuit configured to monitor a separate and different second fluid status indicator of a non-pulmonary fluid status, and a controller coupled to the first and second fluid status monitoring circuits, and a therapy circuit coupled to the controller. The controller is configured to use information about the first and second fluid status indicators to determine a therapy control signal to control a therapy, and the therapy circuit is configured to provide therapy in response to the therapy control signal to adjust at least one of the pulmonary fluid status or the non-pulmonary fluid status.

Devices and methods for treatment of heart failure and associated conditions

Devices and methods for use of identification, treatment and/or management of heart failure and/or associated conditions. Methods may include providing a baroreflex therapy system, providing an implantable measurement device proximate a blood vessel of a patient, the implantable measurement device including a plurality of electrodes, determining an impedance of the blood vessel with the implantable measurement device over a time period of at least one cardiac cycle, generating at least one signal representative of a pressure waveform based on the impedance, activating, deactivating or otherwise modulating the baroreflex therapy system to deliver a therapy to treat heart failure based at least in part on the at least one signal representative of the pressure waveform.

Disclosed herein, among other things, is system for thermal neuroinhibition. According to an embodiment, the system includes at least one implantable fluid-filled conduit adapted to be placed adjacent to a neural target. The system also includes an implantable housing including a power source, a heat pump deriving power from the source and connected to the conduit, and a controller within the housing. The controller is connected to the heat pump, and is adapted to control the heat pump to effect fluid flow in the conduit to cool the neural target using electromechanical refrigeration to reversibly inhibit neural activity as part of a medical treatment.

Systems and methods for thermal neuroinhibition

A system for stimulating a baroreflex of a patient that includes a first light source with a first emitter for emitting a first light, the first emitter at a first location proximate a target tissue having baroreceptor cells, and a second light source including a second emitter and for emitting a second light, the second emitter at a second location proximate the target tissue. The system also includes a control circuit coupled to the first and the second light sources, the control circuit configured to activate the first and the second light sources such that the first light traverses a first pathway to arrive at and penetrate the first portion of the target tissue and the second light-like traverses a second pathway to arrive at and penetrate the second portion of the target tissue, thereby stimulating the baroreceptor cells and activating a baroreflex of the patient.

Baroreflex modulation using light-based stimulation

Devices and methods of use for identification, treatment and/or management of heart failure and/or associated conditions. An exemplary device may include a first sensor configured to monitor a parameter indicative of a fluid level in a pulmonary circulation of a patient, a second sensor configured to monitor a parameter indicative of a fluid level in a non-pulmonary circulation of a patient, and a control system coupled to the first sensor and second sensor. The control system is configured to provide a baroreflex therapy to the patient based at least in part on the parameter indicative of a fluid level in a pulmonary circulation and the parameter indicative of a fluid level in a non-pulmonary circulation. The baroreflex therapy adjusts at least one of the fluid level in the pulmonary circulation and the fluid level in the non-pulmonary circulation.

An apparatus and method for adjusting the performance of an implanted device based on data including contextual information. Contextual information, including operational and performance data concerning the implanted device as well as the patient with the implanted device, is stored by a portable electronic device. In one embodiment, the portable electronic device is adapted for battery operation and includes a personal digital assistant (PDA). The portable electronic device is adapted for use as an interface to conduct wireless communications with the implanted device. In one embodiment, the portable electronic device interfaces with a clinical programmer for use by a physician.

Method and apparatus for establishing context among events and optimizing implanted medical device performance

Devices and methods of use are described for identification, treatment, and/or management of heart failure and/or associated conditions. An exemplary system may include a baroreflex activation device configured to be implantable proximate a blood vessel of a patient, a measurement device configured to be implantable proximate a blood vessel, and a control system coupled to the baroreflex activation device and the measurement device and in communication with a blood pressure sensing means. The control system is programmed to automatically determine pressure waveform data from the measurement device over a time period of at least a portion of one cardiac cycle, determine a patient physiological parameter based on the pressure waveform data, and compare the patient physiological parameter to a blood pressure measurement taken from the blood pressure sensing means.

Systems and methods for sleep state classification involve detecting conditions related to sleep, including at least one condition associated with rapid eye movement (REM) sleep. Additionally, a condition modulated by the sleep-wake status of the patient may be detected. A medical system that is partially or fully implantable incorporates sensors and circuitry for detecting and processing the sleep-related signals. A sleep state processor classifies the patient's sleep state based on the sleep-related signals. Sleep state classification may be used in connection with the delivery of sleep state appropriate therapy, diagnostic testing, or patient monitoring.

Sleep state classification

The present invention provides systems, devices, and methods for using the same for activating (stimulating) the baroreflex system of a patient using a baroreflex activation system with incrementally changing therapy intensity by sensing/monitoring/interpreting sensed data.

Baroreflex activation therapy with incrementally changing intensity

A method of determining one or more physiological parameter of a patient by providing a plurality of implantable electrodes proximate a blood vessel of the patient, applying a measurement signal through the plurality of electrodes, the measurement signal having a known parameter, obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter, calculating vascular impedance based on the measurement signal and the resultant signal, and calculating a physiological parameter based on the vascular impedance. In some embodiments, the physiological parameter is utilized to modify a therapy signal controlling therapy delivered to the patient.

Measurement of patient physiological parameters

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Roseville, MN, United States of America

Eric G Lovett