Nps Pharmaceuticals, Inc.

Smithkline Beecham Corporation

Other

The Brigham and Women's Hospital, Inc.

Eric G Del Mar

James Francis Callahan

Maria Amparo Lago

Bradford C Van Wagenen

Robert M Barmore

Derek Sheehan

Linda Sue Southall

Mervyn Thompson

Richard McCulloch Keenan

Nikesh R Kotecha

Pradip Kumar Bhatnagar

Joelle Lorraine Burgess

Thomas The Nguyen

William M Bryan

Robert L Smith

Edward M Brown

Manuel F Balandrin

James E Garrett

Raul R Calvo

Steven C Hebert

Edward F Nemeth

Raul Rolando Calvo

The present invention features calcilytic compounds. 'Calcilytic compounds' refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.

Calcilytic compounds

Novel calcilytic compounds and methods of using them are provided.

The present invention features calcilytic compounds. &ldquo;Calcilytic compounds&rdquo; refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.

The present invention features calcilytic compounds. &ldquo;calcilytic compounds&rdquo; refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.

Novel calcilytic compounds, pharmaceuticals compositions cotaining said compounds and their use as calcium receptor antagonists.

Novel arylalkylamino compounds exhibiting calcilytic properties are provided.

Method of using calcilytic compounds

The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.

Method of screening calcium receptor-active molecules

Growing community of inventors

Salt Lake City, UT, United States of America

Eric G Del Mar