Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Ipsen Pharma S.a.s.

Centre National De La Recherche Scientifique

Ipsen Pharma

Eric Ferrandis

Christophe Thurieau

Lydie Francine Poitout

Valérie Brault

Beng Poon Teng

Christine Sohier

José-Antonio Camara Y Ferrer

Zheng Xin Dong

Jean Martinez

Jean-Grégoire Marin

The present invention relates to novel somatostatin analogs, dimers thereof, and methods of using the same to treat various diseases. Naturally occurring somatostatins (SSTs), which are also known as somatotropin release-inhibiting factors (SRIFs), have diverse biological effects in many cells and organs 10 throughout the body. They are produced by normal endocrine, gastrointestinal, immune and neuronal cells, as well as by certain tumors (Patel, Y. C, Frontiers in Neuroendocrinology, 20(3): 157-198 (1999); Froidevaux, et al., Biopolymers, 66(3): 161-83 (2002)).

Somatostatin analogs and dimers thereof

A subject of the present application is new benzimidazole derivatives of formula in which A, Y, R, R, Rand Rrepresent different variable groups. These products have an antagonist activity of GnRH (Gonadotropin-Releasing Hormone). The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.

Benzimidazole derivatives and their use as a medicament

The present invention relates to peptides with anti-proliferative activity, of sequence SEQ ID No. 1, SEQ ID No. 2 or SEQ ID No. 3.

Peptides with anti-proliferative activity

A process for preparing recombinant heterocarpine with the complete sequence of heterocarpine (SEQ. ID. NO. 10), expression vectors comprising a polynucleotide encoding for heterocarpine, host cells transformed or transfected by said expression vectors as well as a process for obtaining heterocarpine by means of said transformed or transfected host cells are described where in the recombinant heterocarpine obtained is used to treat cancer.

Method for preparing recombinant heterocarpine

Benzimidazole derivatives and their use as GnRH antagonists

A method of treating cancer dependent on growth factor GHRH in warm-blooded animals in need thereof with an isolated protein extended for

Heterocarpine, a plant-derived protein with anti-cancer properties

The invention relates to a human GHRH-binding protein (human Growth Hormone-releasing hormone). Said protein, which is obtained from theplant, can be used to prepare medicaments intended to antagonise the effects of GHRH and to treat proliferative diseases (particularly cancer), acromegaly or diabetic nephropathies and retinopathies.

Heterocarpine, a human GHRH-binding protein

The invention concerns a novel protein modulating cancer cell proliferation. The proteins encoded by the polynucleotides of the invention enable to determine the degree of malignity of abnormal cell proliferation.

Growing community of inventors

Saint Remy les Chevreuse, France

Eric Ferrandis