Cytiva Sweden Ab

Ge Healthcare Bio-sciences Ab

Global Life Sciences Solutions USA LLC

Eric Faldt

Klaus Gebauer

Ralph Stankowski

Karl Liderfelt

Nils Norrman

Ronnie Palmgren

Ola Lind

Patric Fricking

Andreas Castan

Tomas Yngve Agren

Thomas Falkman

Nachiket Karmarkar

Patrick Jonsson

Hanna-Leena Saukkonen

Matthew Ouellette

Benjamin Brown

Lauren Lisle

Shanice Jones

Jesper Hedberg

Niklas Jungnelius

Anita Solbrand

Aseptic connectors are described. An aseptic connector includes a first connection unit and a second connection unit provided with at least one first and second openings orientated to substantially coincide when said first and second connection units are connected to each other. The first and second openings are sealed by at least one film, so that the contact between the film and each connection unit is aseptic. The at least one film is adapted to be mated with a corresponding film on the other connection unit; and the mated films are adapted to be pulled out together two and two after mating such that corresponding first and second openings are mated aseptically.

Aseptic connector

The invention discloses an immunoglobulin-binding magnetic bead, comprising a porous matrix and one or more magnetic particles embedded in said matrix, wherein said matrix comprises a porous polymer and at least 10 mg/ml Fc-binding proteinaceous ligands covalently coupled to said porous polymer.

Magnetic immunoglobulin-binding particles

The invention discloses a condenser for a bioreactor exhaust, comprising: an inlet () adapted to be fluidically connected to a bioreactor exhaust port (), a cooling chamber () fluidically connected to the inlet and via a filter device () to an outlet (), a cooling conduit () in contact with the cooling chamber, a heating conduit () in contact with the filter device and a vortex tube () arranged to convey a cold gas stream through the cooling conduit and to convey a hot gas stream through the heating conduit.

Bioreactor condenser

An apparatus for minimizing dead leg spaces in a container or tubing includes a first member having a flange for attaching the first member to a wall of the container or tubing, the flange having at least one aperture, and a second member rotatably coupled to the first member, the second member having an upper end having at least one aperture, and an open distal end. The second member is rotatable relative to the first member between a closed position where the at least one aperture of the second member is misaligned with the at least one aperture in the flange to prevent the passage of fluid, and an open position where the at least one aperture of the second member is aligned with the at least one aperture in the flange to allow for the passage of fluid.

System, method and apparatus for minimizing dead legs in a bioreactor system

A filter holding device () arranged for providing at least one filter () inside a flexible bag (), said filter holding device comprising attaching means (--) for attaching the filter holding device to an inner surface of the flexible bag such that the at least one filter held by the filter holding device is provided at a distance from the inner surface of the flexible bag.

Filter holding device

The present invention relates to a product and method for cell preservation, such as cell banking of any type of cells for subsequent scientific or medical use. More closely, the invention relates to a product and a method for cryopreservation of cells using vacuum tubes provided with freeze media/cryopreservation liquid.

Product and method for cell preservation

The invention relates to a An aseptic connector comprising a first connection unit () provided with a first terminal end surface () and a second connection unit () provided with a second terminal end surface (); said first and second terminal end surfaces are each provided with at least one first and second opening (), which openings are orientated to substantially coincide when said first and second connection units are connected to each other; said first and second openings are sealed by at least one film () arranged on said first and second connection units, so that the contact between the film and each connection unit is aseptic; said at least one film is adapted to be mated with a corresponding film on the other connection unit when said first and second connection units are connected to each other; and said mated films are adapted to be pulled out together two and two after mating such that corresponding first and second openings in said first and second terminal end surfaces are mated aseptically. At least two first ports () are arranged on the first connection unit, which first ports have fluid connection with the at least one first opening () in the first terminal end surface; and in that at least one second port () is arranged on the second connection unit, which the at least one second port has a fluid connection with the at least one second opening () in the second terminal end surface.

The invention discloses a flexible bag for cell cultivation, comprising a cultivation compartment and at least one dialysis compartment, wherein the dialysis compartment(s) is/are delimited from the cultivation compartment by one or more dialysis membranes and is/are fluidically connected to a first and a second port in the bag.

Cell culture bag with internal dialysis membrane

An apparatus for substantially sterile connection of flexible tubing, including at least one tubing holder, which is adapted to receive one or more lengths of flexible tubing and which is also equipped with one or more sterilant applicators. The sterilant applicator is adapted to apply a sterilant to the length of tubing when the tubing length is received in the tubing holder. At least one cutter, which is movable in relation to the tubing holder and adapted to cut the length of tubing. A connector holder, which includes a compartment housing and a substantially sterile tubing connector. The connector holder is movable in relation to the tubing holder to a position where the length of tubing and the sterile tubing connector are aligned and can be urged together.

Apparatus and method for making a sterile connection of flexible tubing

The present invention relates to a device () for delivery of fluid, said device comprising at least two fluid ducts (-) of flexible material, each of which in one end can be connected to a fluid source and in the opposite end is connected to a manifold () having an inlet end and an outlet end, each of said fluid ducts (-) comprising a pinch valve () for closing and opening the duct. According to the invention a check valve () is disposed in at least one of said fluid ducts (-) in the end thereof connected to the manifold ().

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Uppsala, Sweden

Eric Faldt