Commissariat a L'energie Atomique

Assistance Publique-hopitaux De Paris

Eric Ezan

Philippe Pradelles

Michel Azizi

Marie-Astrid Sagot

The invention concerns the use of ACE-resistant N-ac&#xe9;tyl-Ser-Asp-Lys-Pro analogues for preparing a reagent or marker adapted to measure a glomerular filtration rate.

Use of a tetrapeptide AcSDKP (SEQ ID No. 1) analog resistant to the angiotensin I converting enzyme for measuring glomerular filtration rate in a human or an animal and kit containing same

The present invention relates to a method for detecting and/or measuring the concentration of fluoride (F) or hydrogen fluoride (HF) in a sample, comprising the steps consisting of bringing said sample, in aqueous solution, into contact with a silylated organic compound in order to obtain a measurement solution, with said silylated organic compound being desilylated when it is in the presence of hydrofluoric acid or a fluoride, with the silylated organic compound and the desilylated organic compound being able to be detected and/or measured separately from each other; and detecting and/or measuring, in said measurement solution, the appearance of the desilylated against compound or the disappearance of the silylated organic compound, which takes place if fluoride or hydrogen fluoride is present in the sample. The method enables the presence of hydrogen fluoride or of fluorine to be detected very easily and expediently at concentrations of 10l of HF/10l of air (10 ppb) or else of 0.5 to 1 &#x3bc;g/ml of HF in solution. The kit of the present invention comprises the components which are required for implementing this method. The method of the invention makes it possible to detect fluorine at concentrations of the order of 0.001 &#x3bc;g/ml.

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Malakoff, France

Eric Ezan