Givaudan S.a.

Eric Eichhorn

Boris Schilling

Laurent Fourage

Esther Locher

Denis Wahler

Alix Rousseaux

Ghislain Sanhaji

Sandrine Noel

Felix Flachsmann

Andreas Goeke

Christophe Ullmann

Jean-Pierre Barras

Sylvie Morel

Squalene Hopene Cyclase (SHC) enzymes and variants thereof and their uses for making (−)-Ambrox from homofarnesol and Ambra oxide from bishomofarnesol.

Squalene hopene cyclase (SHC) variants

A method for purifying a crude flavor or perfumery or cosmetic ingredient or intermediate, for example crude (−)-Ambrox, comprising a number of washing steps, the products of said method, and uses of said product.

Method for purifying (−)-Ambrox

An enzyme-mediated method for the production of acetates as defined by formula (I), the products of said method, and uses of said products.

Conversion of farnesylacetone to homofarnesylacetate by baeyer-villiger monooxygenase

A solid form of (−)-Ambrox formed by a bioconversion process.

Solid form of (−)-Ambrox formed by a bioconversion of homofarnesol in the presence of a biocatalyst

There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (−)-Ambrox and SHC/HAC enzymes in methods to prepare (−)-Ambrox.

Enzymes and applications thereof

An enzyme-mediated method for the production of 3a-ethyl-6,6,9a-trimethyldodecahydronaphtho[2,1-b]furan, the products of said method, and uses of said products.

Enzyme mediated process

A method for making 2-oxygenated decalins, and products thereof.

Method of making 2-oxygenated decalins from isoprenoids using a squalene-hopene cyclase

A solid form of (&#x2212;)-Ambrox formed by a bioconversion process.

Solid form of (-)-Ambrox formed by a bioconversion of homofarnesol in the presence of a biocatalyst

There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (&#x2212;)-Ambrox and SHC/HAC enzymes in methods to prepare (&#x2212;)-Ambrox.

Solid form of (&#x2212;)-Ambrox formed by a bioconversion of homofarnesol in the presence of a biocatalyst

A method of isolating and purifying (&#x2212;)-Ambrox from a reaction mixture comprising (&#x2212;)-Ambrox and one or more of the compounds (II), (III) and (IV) 

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Zurich, Switzerland

Eric Eichhorn