Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Commissariat a L'energie Atomique

Pierre Fabre Medicament

Centre National De La Recherche Scientifique

Les Laboratories Servier

Université Paris-Sud 11

Les Laboratoires Servier

Eric Doris

Edmond Gravel

Bertrand Tavitian

François Lefoulon

Laurent Vivien

Marc Nicolas

Bernard Rousseau

Frédéric Duconge

Nicolas Izard

Paul Hellier

Didier Boquet

Emerson Giovanelli

Etienne Gaufres

Thomas Arnauld

Lionel Moisan

Sébastien Comesse

Nicolas Mackiewicz

Laurent Larquetoux

Sébastien Leroux

Julien Ogier

The invention relates to polymerized micelles of size inferior to 100 nm for in vivo diagnosis, in particular of cancer. The polymerized micelles of the invention comprise a diagnostic agent and an amphiphilic polymer obtainable by the polymerization of an amphiphilic monomer, said monomer comprising: a lipophilic chain comprising a polymerizable vinylic or diacetylenic group, and a hydrophilic head comprising a polyoxyethylene or polyoxypropylene chain. The invention finds application in the pharmaceutical field, in particular.

Polymerized micelles for diagnosis

A component or device is provided for the detection or the measurement in parallel of one or more specific types of biological or chemical target products. This component includes a group of nanotubes selected and/or functionalized to interact with the target product, around an optical waveguide. Thus, an optical coupling is produced between the optical waveguide and one or more optical characteristics of these nanotubes, the modifications of which are evaluated in the presence of the target product. In addition, a method is provided for manufacturing and preparing such a component or device, and a detection method using them, as well as a post-manufacture preparation method comprising a specific functionalization for different target products starting from the same type of pluripotent generic component. Also provided is a family of PFO-based functionalization polymers.

Multi-target photonic biosensor, and method for manufacturing and preparing same

The present invention relates to the use of the vinyl quinuclidine enantiomer (R) of the following formula 2 as a synthesis intermediate in the preparation of (R)-mequitazine.

Vinyl quinuclidine useful as a synthesis intermediate in the preparation of (R)-mequitazine

Polymerized micelles comprising polymerized amphiphilic molecules obtained starting from amphiphilic molecules having one or two lipid chains each comprising one or two polymerizable moieties and linked to a polar head.

Polymerized micelles

The fluorinated derivatives of catharanthine according to the invention respond to the general formula I: in which:

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Orsay, France

Eric Doris