Centre National De La Recherche Scientifique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Institut National De La Sante Et De La Recherche Medicale

Eric Denarier

Sylvain Rault

Annie Andrieux

Didier Job

Christophe Bosc

Patrick Dallemagne

Laurence Lafanechère

Peggy Suzanne

Renaud Prudent

Serge Perato

Aurélien Lesnard

Muriel Vernet

Marc Billaud

Jean-charles Lancelot

Audrey Vernet

Lauralie Peronne

The invention concerns a compound of formula (I), Formula (I), wherein R, Rand Rare independently selected form the group consisting of: —a hydrogen atom, —a halogen atom, —an alkyl group, linear, cyclic or branched, saturated or unsaturated, possibly substituted, comprising from 1 to 10 carbon atoms, —an acyl group comprising from 1 to 10 carbon atoms, —a carboxyl group, —an amido group comprising from 1 to 10 carbon atoms, and —an imino group, possibly substituted by an alkyl group, linear, cyclic or branched, saturated or unsaturated, and wherein R, R, Rand Rare independently selected form the group consisting of: —a hydrogen atom, —a halogen atom, —a hydroxyl group, —an alkyl group, linear, cyclic or branched, saturated or unsaturated, possibly substituted, comprising from 1 to 10 carbon atoms, —an alkoxy group comprising from 1 to 10 carbon atoms, —an acyl group comprising from 1 to 10 carbon atoms, —a carbonate group from 1 to 10 carbon atoms, —a carboxyl group, and —a cyano group.

Carbazole derivatives sensitizing cells to anti-cancer agents

The invention concerns transgenic or recombinant non-human mammals, wherein the expression of the gene coding for a microtubule associated protein (MAP) is modified (STOP gene) (inactivation or overexpression) and their uses in screening medicines useful in schizophrenia and schizo-affective disorders, with anxious, paranoiac or depressive component.

Transgenic or recombinant non-human mammals and their uses in screening psychoactive medicines

Growing community of inventors

Grenoble, France

Eric Denarier