Cvrx, Inc.

Eric D Irwin

Martin A Rossing

Stephen L Bolea

Peter Trexler Keith

Robert S Kieval

Matthew M Burns

Thomas R Hektner

Bruce J Persson

David J Serdar

Aaron J Hjelle

David W Mayer

Thomas P Crowley

Gina L Hansen

Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

Electrode structures and methods for their use in cardiovascular reflex control

Connection structures on an extra-vascular electrode lead body improve strain relief and strengthen the transition region where electrical conductors carried by the lead body are joined to individual electrodes at the distal end of the lead. The electrodes include structure or mechanisms for externally securing the electrode assembly to a body part. A first connection structure is located on the lead body proximal the electrodes to anchor the lead body to a first anchor location in the body that generally moves in concert with the body part. A second connection structure is located on the lead body proximal to the first connection structure to anchor the lead body to a second anchor location that is at least partially independent of movement of the body part. The first and second anchor location are offset by a distance that is less than a distance between the first and second connection structures to provide strain relief for the electrodes.

Connection structures for extra-vascular electrode lead body

An apparatus and a system can chronically and automatically measure a physiologic parameter associated with the high pressure side of the vasculature and/or regulate blood pressure based upon the measured parameter. The apparatus may be made up of a transducer, a baroreflex activation device having one or more electrodes, and a lead having two or more conductors. The system can measure a physiologic parameter and selectively administer a therapy, such as, for example, electro-stimulation of baroreceptors, based upon the measurement. The transducer for measuring the physiologic parameter can be chronically implanted in the high-pressure side of the vasculature. The implantation method may include intravascularly positioning the transducer in the external carotid artery in such a way that the transducer is first introduced into the arterial vasculature through the superior thyroid artery.

Method and system for implantable pressure transducer for regulating blood pressure

Devices, systems and methods by which the blood pressure, nervous system activity, and neurohornonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably in the carotid sinus. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

Electrode designs and methods of use for cardiovascular reflex control devices

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Minneapolis, MN, United States of America

Eric D Irwin