Sartorius Stedim Fmt Sas

Sartorius Stedim Biotech Gmbh

Eric Chevalier

Frederic Bernard

Magali Barbaroux

Isabelle Valerie Christine Gay

Magali Dominique Corinne Barbaroux

Frédéric Bernard

Isabelle Valérie Christine Gay

A frame delimits an inside space and includes a peripherally closed side wall and two transverse openings or one transverse opening and a transverse end wall. It is capable of allowing the airtight engagement of the open free edge of a side wall in film form of a receptacle that is at least partially deformable. It is specially designed for the creation of a 3D container. The frame is also able to act as a support for at least one functional port or attachment port of a functional element. Its axial size is adequate for delimiting a space of a size that is at least equal to the axial dimension of the functional element, so that the latter can be completely housed within the inside space.

3D container with rigid frame, deformable container and functional means for processing the content and including an inner member for biopharmaceutical applications

A processing receptacle for a biopharmaceutical product includes a pocket configured to accommodate the biopharmaceutical product that can assume a flat-folded state, an expanded state, or any intermediate state in between, a processing element having an active inner portion, a rigid protective chamber to protect the processing element, and at least one opening for introducing the product into the receptacle and/or for draining the contents from the receptacle. A portion of the protective chamber is rigidly attached to a portion of the pocket and movement of the pocket up or down brings about movement of the protective chamber; the processing element and the protective chamber are arranged to be independent from one another relative to their movements. The protective chamber has a variable height that automatically adapts to accommodate the flat-folded, expanded, or intermediate state of the pocket, and in each state of the pocket, the processing element is offset from the side walls and the upper end portion of the pocket, while being adjacent to the lower end portion. A device having such a processing receptacle and a method for processing a biopharmaceutical product utilizing such a device are also presented.

Vessel for processing a biopharmaceutical product including protection means

3D container with rigid frame, deformable container, and functional means for processing the content, and including an internal member for biopharmaceutical applications

A mixing process, a spraying and dispersing device, and a mixing device for implementing the process. In the process, components are introduced into a container equipped with introduction elements and mixing elements and the contents are mixed. A mixing facilitator is provided, a spraying and dispersing device that can be connected to the container at one of its introduction element is provided, able to be in an active functional state in which it makes it possible to spray and to disperse a liquid in the container, and then, in a first phase, the base of the contents and then the components to be mixed are introduced into the container, without filling the latter, and in a second phase, the mixing facilitator is introduced into the container via an introduction element, and it is sprayed and dispersed to the components to be mixed by the spraying and dispersing device that is put into the active functional state.

Mixing in a container of content having a base component and a component to be mixed

A first piece mounted in a fixed and rigid manner on a rigid annular collar of a second piece having an end opening, includes a transversal wall; an annular wall forming a skirt, whose inner face includes a part having a larger diameter and a part having a smaller diameter; a holding toric body adjacent to the inner face, deformable between a retracted state and an expanded state, and filled with a swelling medium; and at least one inlet/outlet port for the swelling media, communicating with the holding body. The first piece is dimensioned in relation to the collar, so as to enable the first piece to be slipped onto, or removed from, the second piece, when the holding body is in the retracted state, and to be mounted onto the collar in a fixed, rigid and tight manner, when the holding body is in the expanded state.

Assembly having a holding toric body for closing an annular collar, or connecting to same, which can be rapidly positioned and removed and used in the biopharamaceutical field

A vessel includes: a pocket capable of assuming a folded state and an expanded state, processing element including an active inner portion; protection element including a side wall, a lower portion and an upper portion defining an inner space, the lower portion being attached to the upper portion of the pocket, the active inner portion being provided in the inner space when the pocket is in the folded state, the peripheral portion of the inner space about the processing element defining a protection chamber; at least one insertion and/or draining opening. The active inner portion is provided inside the pocket adjacent to the lower end portion thereof, the processing element and the protection element are independent in terms of their movements, and the height of the protection chamber is variable and automatically adapts itself based on respectively, the flat-folded, unfolded and expanded states or any intermediate state of the pocket.

A mounting assembly is provided including a first piece mounted in a fixed, detachable, and sealed manner, on a rigid, annular collar of a second piece having an end opening. The first piece includes an annular peripheral wall having an inner face configured to contact an outer face of the collar. The first piece includes a transverse wall that can enter the opening, and an annular wall forming a skirt, the inner face of the skirt including a larger diameter part, a smaller diameter part, and an intermediate part configured to contact with conjugated parts of the outer face by clamping. The transverse wall and the skirt form one component and are made of a highly flexible material enabling the first piece to be brought into an intermediate state in which the first piece is enlarged to be removed from the second piece, while retaining elastic deformation.

Assembly having a self-clamping skirt for closing an annular collar or connecting to same, which can be rapidly positioned and removed, and used in the biopharmaceutical field

A device for connecting to a vessel an accessory has an active portion that includes a first, second and third member and a chamber. The first member ensures rigid attachment of the device to the vessel, defines a passageway, acts as a holder for the second member and as a translation guide between a first distal state and a second proximal state, contributes as a guide for the third member and participates in defining the chamber. The second member acts as a holder for the third member rigidly attached thereon, defines a mobile member capable of sliding between the first distal state and the second proximal state. The third member includes a head, and acts as a holder for the accessory rigidly attached thereon, defines a mobile member capable of sliding between the first distal state and the second proximal state, ensures in the first distal state the tight closing of the opening using the head, ensures in the second proximal state a protection of the active proximal portion using the head, and participates in defining the chamber.

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Paris, France

Eric Chevalier