The University of Melbourne

Oral Health Australia Pty Ltd

Csl Limited

The Victorian Dairy Industry Authority

Other

Dairy Australia Limited

Oral Health Austrailia Pty. Ltd.

Victorian Dairy Industry Association

The Austin Research Institute

Neil Martin O'brien-simpson

Nada Slakeski

Eric Charles Reynolds

Cheers, Christina

Stambas, John

Neil Martin O'Brien-Simpson

Stuart Geoffrey Dashper

Neil Martin O'Brien Simpson

Keith J Cross

Paul David Veith

Ching Seng Ang

Ian George Barr

Greg GuangHua Qiao

Chao Guang Chen

Shu Jie Lam

Anton Richard Blencowe

Gert Hoy Talbo

Stuart G Dashper

Marina Malkoski

Martin J Tyas

Anne Hendtlass

Peter Singh Bhogal

Elsdon Storey

Wallace A McDougall

Rita Ann Paolini

Rishi Delan Pathirana

Guang Gao Chen

George Ian Barr

Ian Farquhar Campbell Mckenzie

Neil Martin O`BRIEN -Simpson

Geoffrey Allan Pietersz

John Stambas

Christina Cheers

Neil Martin O'brien Simpson

Martin John Tyas

Neil Martin O'brien-Simpson

Neil Martin O'BRIEN Simpson

Stuart Geoffrey Daspher

The present invention relates to improved phosphopeptide stabilised amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complexes and compositions containing those complexes. Methods of making the complexes of the invention and of treatment dental hypersensitivity are also provided. In one embodiment, the invention provides a stannous-associated phosphopeptide (PP) stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complex having a stannous ion content of equal to, or greater than, 1 mole of stannous per mole of PP but less than 4 moles of stannous per mole of PP.

Complexes for treating sensitivity

This invention relates to antibacterial compounds and compositions thereof. The invention also relates to the use of the compounds and compositions in methods of treating bacterial infections, particularly those bacterial infections including bacteria that exhibit antibiotic resistance. More specifically, the present invention provides a star shaped peptide polymer comprising a multifunctional core with a plurality of terminal arms extending therefrom, wherein the terminal arms are statistical or random peptide copolymers of at least a cationic amino acid residue and a hydrophobic amino acid residue.

Modified antibacterial compositions and methods

The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.

Stabilized stannous compositions

The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.

Compositions and methods for dental mineralization

The present invention relates to compositions and their use for oral care. In particular, the compositions and methods are for maintaining oral health and/or treating various oral conditions such as gingivitis. The present invention relates to methods and uses of stabilized amorphous calcium phosphate (ACP) and/or stabilized amorphous calcium fluoride phosphate (ACFP) in the preparation of a medicament for reducing pathogenic oral bacteria at an oral site in an individual; increasing commensal oral bacteria at an oral site in an individual; decreasing the proportion of pathogenic oral bacteria at an oral site in an individual; inhibiting oral dysbiosis; reducing gingival inflammation in an individual in need thereof; treating gingivitis in an individual in need thereof; and treating chronic gingivitis in an individual in need thereof.

Treatment for periodontitis

Disclosed areantibodies raised against a chimeric or fusion protein, wherein the chimeric or fusion protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein (A) the first peptide comprises a region of atrypsin-like enzyme and (B) the second peptide or polypeptide comprises an adhesin domain of

Antibodies for prevention, treatment and diagnosis ofinfection

The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.

Fluoride composition and methods for dental mineralization

This invention relates to compositions including antibacterial compounds. The invention also relates to the use of the compositions in methods of treating bacterial infections. In one aspect the present invention also provides a method of increasing the susceptibility of bacteria to the anti-bacterial activity of a compound, the method comprising contacting the bacteria with a star shaped peptide polymer of the invention, thereby increasing the susceptibility of the bacteria to the anti-bacterial activity of the compound. Preferably, the method further includes the step of contacting the bacteria with the compound for which the bacteria have increased susceptibility to. The invention is further relates to the combination of a star shaped peptide polymer and an anti-bacterial compound that restore the sensitivity of antibiotic resistant bacteria to antibiotics that are otherwise ineffective when administered alone.

Antimicrobial composition combinations comprising star shaped peptide polymers

Disclosed are methods related to the generation and use of cellular and humoral responses for the prevention and treatment ofrelated conditions and diseases, such as methods of preparingantibodies, comprising immunizing a non-human animal with a chimeric or fusion protein, wherein the protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein (A) the first peptide comprises a region of atrypsin-like enzyme and (B) the second peptide or polypeptide comprises an adhesin domain of

Methods of preparingantibodies

The present invention relates to a phosphopeptide-stabilized amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complex, wherein the complex is formed at a pH of below 7.0. Methods of making such complexes are also provided. The complexes are useful in dental applications, in particular in dental remineralization.

Stabilized calcium phosphate complexes

Growing community of inventors

North Balwyn, Australia

Eric Charles Reynolds