Bristol-myers Squibb Compnay

Zymogenetics, Inc.

Other

Eric Chadwick

Janine M Bilsborough

Sherri L Mudri

Mark J Selby

James William West

Zeren Gao

Steven D Levin

Cameron Brandt

Sean E Doyle

Provided are methods and compositions for treating cancer using an effective amount of a PD-1 antagonist (e.g., an antibody) in combination with a TIM-4 antagonist (e.g., an antibody).

Combination of TIM-4 antagonist and PD-1 antagonist and methods of use

The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.

Method of treating CD155 expressing cancers

Screening method for inhibitors of binding of zBR7R1 to CD155

Use of IL-31 agonists, including IL-31, are used to treat agonists are used to treat asthma, airway hyper-responsiveness or allergic rhinitis. The method comprise inhibiting, reducing, limiting or minimizing production of proinflammatory cytokines and include administration of the IL-31 agonist during sensitization or challenge resulting in the asthma, airway hyper-responsiveness or allergic rhinitis state.

Methods of using IL-31 to treat chronic obstructive pulmonary disease (COPD)

Methods of determining dose of IL-31 agonist to treat pulmonary inflammation

Use of IL-31 agonists, including IL-31, are used to treat agonists are used to treat asthma, airway hyper-responsiveness or allergic rhinitis. The method comprise inhibiting, reducing, limiting or minimizing production of proimflammatory cytokines and include administration of the IL-31 agonsit during sensitization or challenge resulting in the asthma, airway hyper-responsiveness or allergic rhinitis state.

Methods of using IL-31 to treat airway hyper-responsiveness and asthma

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Bellevue, WA, United States of America

Eric Chadwick