Eisai R&d Management Co., Ltd.

Smith Optics, Inc.

Shriners Hospital for Children

Flashtiming LLC

Eric Carlson

Shawn Schiller

Hans J Hansen

Lynn D Hawkins

Atsushi Endo

Sally T Ishizaka

Matthew Mackey

Roch Boivin

Sridhar Narayan

Takashi Satoh

James A Chilson

Dominique Aris

Heather Davis

Scott MacGuffie

Mark Spyvee

Matt Capozzi

Philip S Crosby

Eric Thorsell

Scott Layton

J Lynn Saunders

Nicolas Ramirez

Sean Nemoto

Chikako Ogawa

Brian M Gallagher, Jr

Hans Lindauer

Michael Qualls

Lynn Y Sakai

Nancy Wong

Christina Shaffer

Qian Chen

Sarah J Marlino

Susan J Hayflick

Noe L Charbonneau

Lynn M Marshall

Scott Macguffie

Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Tetrahydropyrazolopyrimidine compounds

Tinted lenses for attenuating ambient light, reducing glare, and improving color discrimination for a user are disclosed. In some embodiments, the lens has uniform transmittance across the visible spectrum with selective filtering of light at 480 nm and 580 nm. In some embodiments, the lens may reduce light in the blue region of the spectrum while maintaining color discrimination. In some embodiments, the level of attenuation provided by the lens may vary based on the intensity of light present while maintaining selective filtering at 480 nm and 580 nm.

Tinted polarized lenses having selective frequency filtering

Eyerwear

A tinted polarized lens for attenuating ambient light reducing glare and improving color discrimination for a user is disclosed. In some embodiments, the lens has uniform transmittance across the visible spectrum with selective filtering of light at 480 nm and 580 nm. In some embodiments, the lens may reduce light in the blue region of the spectrum while maintaining color discrimination. In some embodiments, the level of attenuation provided by the lens may vary based on the intensity of light present while maintaining selective filtering at 480 nm and 580 nm.

The present invention makes use of immunoassays, such as sandwich ELISAs, to profile the circulating concentration of elastic fiber and microfibril fragments in samples from individuals with diseases associated with elastic fiber and/or microfibril degradation. Examples of such diseases include, Marfan's syndrome, aortic aneurysm, and scleroderma. Profiling the concentration of such fragments can be used to diagnose disease and monitor disease progression.

Profiling fragments of elastic fibers and microfibrils as biomarkers for disease

Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Selectively substituted quinoline compounds

Improved systems and methods for timing athletic events. A radio-based starter unit and a radio based timer unit communicate wirelessly via radio. Push buttons/switches and lights and a speaker in the units provide an intuitive, easy to use interface. Handshaking occurs between the starter unit and the timer unit, and lights indicate that the event is ready to start. Real time clocks in the units are synchronized. Upon detection of race or other event start, such as from a starter's pistol, information indicative of the race start time is transmitted from the start unit to the timer unit. A camera in communication with the timer unit provides video frames, and the timer unit encodes and inserts elapsed time information in the video frames, which are then output from the timer unit for review and analysis on a computer.

Systems and methods for timing athletic events

Helmet

The invention relates to the use of hydantoin compounds useful for treating or preventing autoimmune disorders. The present invention also provides compositions and uses thereof.

Hydantoin compounds

Growing community of inventors

Portland, OR, United States of America

Eric Carlson