H. Lee Moffitt Cancer Center and Research Institute, Inc.

University of South Florida

Eric Bruce Haura

Richard Jove

Daniel M Sullivan

Gerold Bepler

Susan E Minton

Carlos A Muro-Cacho

The subject invention pertains to materials and methods for the classification of cancers as sensitive or resistant to treatments based on protein-protein interactions, treatment of cancer, identification of biomarkers, identification of protein-protein interaction modulators, and selection of cancer treatments.

Protein-protein interaction as biomarkers

Methods are provided for predicting responsiveness of cancer cells to chemotherapy by measuring the level of phosphorylated Stat or the level of expression of Survivin in a cancer and comparing the level in the cancer cell to the respective level in a control. Also provided are methods of selecting a chemotherapeutic treatment for a subject diagnosed with cancer by measuring the level of phosphorylated Stat or the level of expression of Survivin in a cancer and comparing the level in the cancer cell to the respective level in a control. Kits for performing the methods are also provided. Methods for modulating Survivin-dependent apoptosis in a cancer cell are also disclosed.

Methods of predicting responsiveness to chemotherapeutic agents and selecting treatments

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Tampa, FL, United States of America

Eric Bruce Haura