Nomir Medical Technologies, Inc.

Bornstein, Eric

Eric Bornstein

Edward L Sinofsky

John Wlassich

Systems and methods are disclosed herein for prophylactic application of near-infrared optical energies and dosimetries to photo-biologically inhibit accelerations or intensifications in biofilm production, after a bacterial or fungal pathogen is challenged with an antibiotic or antifungal agent. This photo-biologic minimum biofilm inhibitory concentration (PMBIC) of infrared light will lower the minimum inhibitory concentration (MIC) necessary of an antibiotic and/or antifungal molecule necessary to decrease bacterial and fungal pathogens in human tissues. These systems and methods will only target undesirable microbial cells.

Apparatus, system, and method for generating photo-biologic minimum biofilm inhibitory concentration of infrared light

A method is disclosed of providing photo-chrono-therapy to a wound site in a human or animal subject, the method including: determining or receiving subject circadian and/or ultradian cycle information indicative of a biological rhythm(s) of the subject; and based on the subject cycle information, delivering a photo-chrono-dose of infrared treatment light to the wound site with wavelengths within at least one infrared wavelength range and having a dosimetry configured to promote healing at the wound site.

Near-infrared enhancement of circadian and ultradian spatiotemporal cellular coordination

An optical delivery apparatus is disclosed including: an optical fiber extending between a distal end having a distal end face and a proximal end having a proximal end face, an optical element positioned to receive the light emitted from the distal end face and direct the light to an illumination region; and a non-metallic housing containing the optical fiber and the optical element and maintaining the relative position of the optical fiber and the optical element.

Therapeutic light delivery apparatus, method, and system

Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e.g., loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries.

Near infrared microbial elimination laser systems (NIMELS)

Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (&#x394;&#x3a8;-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials &#x394;&#x3a8; of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential &#x394;&#x3a8;, the affiliated weakening of the proton motive force &#x394;p, and the associated lowered phosphorylation potential &#x394;Gp. Within the area of irradiation exposure, the decrease in membrane potentials &#x394;&#x3a8; will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.

Near-infrared electromagnetic modification of cellular steady-state membrane potentials

Optical methods and devices are provided for the reduction of the lipid content of adipocytes without significant heat or intolerable adverse effect on the cells and their surrounding tissues. The optical method and device can be used to irradiate adipose tissue through the skin with non-thermal and non-destructive effects by application of near infrared (NIR) irradiation at selected wave bands in selected ranges to affect modulation of innate enzymatic processes involved in lipolysis, lipogenesis, leptin secretion, adiponectin secretion, and/or glucose absorption.

Optical method and device for modulation of biochemical processes in adipose tissue

Near infrared microbial elimination laser systems (NIMEL)

Provided herein are methods and compositions useful for the treatment of periodontal disease exploiting optical and thermal emissions of near-infrared laser systems and fibers in order to target chromophore-stained biofilm while minimizing damage to healthy tissues.

Use of secondary optical emission as a novel biofilm targeting technology

A system and process for thermolytic eradication of bacteria and biofilm in the root canal of a human tooth involve an elongated and flexible optical probe and a laser oscillator that provides the probe with low infrared energy. The optical probe is sufficiently long for insertion into substantially the entire length of the root canal of the tooth. The optical probe causes lateral dispersion of the radiation from the probe throughout the root canal. The radiation is provided at an energy density and for a period of time that are necessary to selectively target bacteria and live biofilm in the dentinal tubules of an entire root canal system, at once, thereby (1) inhibiting creation of a blackbody 'hot tip', and (2) inducing laser interstitial thermotherapy (LITT) within the root-canal space.

Instrument for delivery of optical energy to the dental root canal system for hidden bacterial and live biofilm thermolysis

An instrument is provided to enables a dental professional to subject a surgical site simultaneously to () mechanical cutting, scraping and grinding, and () laser trimming and cauterization. As a result, simultaneous removal of diseased tissue and destruction of residual bacteria is enabled. The instrument comprises a hollow shank having, a rearward fitting, and a forward contact head. Within shank extends a fiber optic bundle. As shown, laser energy is delivered from a laser through the fitting and the laser bundle to the contact head. In the contact head are a surgical blade and an exit window for the laser energy.

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Natick, MA, United States of America

Eric Bornstein