Aventis Pharma S.a.

Eric Bacqué

Michel Tabart

Serge Mignani

Jean-Luc Malleron

Fabrice Viviani

Jean-Christophe Carry

Baptiste Ronan

Patrick Mailliet

Michel Evers

Youssef El-Ahmad

Antony Bigot

Fabienne Thompson

Conception Nemecek

Youssef El Ahmad

Sylvie Wentzler

Philippe Hubert

Cécile Combeau

Guy Pantel

Gérard Puchault

Françoise Tetot

The present invention relates to novel compounds derived from indazoles or indoles of formula (1) or formula (2), to methods for treating tumors or cancerous cells with compounds of formula (1) or formula (2) and to pharmacaetutical compositions comprising a pharmaceutically acceptable carrier and a compound of formula (1) or formula (2) 

Indazole or indole derivatives, and use thereof in human medicine and more particularly in oncology

Heterocyclylalkylpiperidine derivatives of general formula (I)in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as any salt thereof.

Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them

The present invention relates to group A streptogramin derivatives of general formula (I) and processes for preparing the same:which has particularly advantageous antibacterial activity.

Streptogramin derivatives, their preparation and compositions containing them

Quinolylpropylpiperidine derivatives of general formula (I) in which Ris hydrogen, halogen, hydroxyl, amino, alkylamino, dialkylamino, hydroxyamino, alkoxyamino or alkylalkoxyamino and Ris hydrogen, or Rand Rform an oxo, Ris carboxyl, carboxymethyl or hydroxymethyl, Ris alkyl either substituted with phenylthio optionally substituted with halogen, hydroxyl, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkoxycarbonyl, cyano or amino, or with cycloalkylthio (3 to 7 members) optionally substituted with halogen or trifluoromethyl, or with heteroarylthio (5 to 6 members and 1 to 4 heteroatoms chosen from N, O and S), optionally substituted with halogen, hydroxyl, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkoxycarbonyl, cyano or amino or Ris propargyl substituted with phenyl or heteroaryl as defined above, Ris alkyl, alkenyl-CH&#x2014; or alkynyl-CH&#x2014;, cycloalkyl or cycloalkylalkyl, in their various isomeric forms, separate or as mixtures, and also their salts, their preparation process and intermediates and the compositions containing them. These novel derivatives are potent antibacterial agents.

Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor

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Gif sur Yvette, France

Eric Bacqué