Avent, Inc.

Soin Neuroscience, LLC

Kimberly-clark Worldwide, Inc.

Avent Investment, LLC

Eric Anthony Schepis

Phillip A Schorr

Amol Soin

David M Page

Ryan Caldwell

Natalia Alexeeva

Shyamy R Sastry

Leah M Roldan

Jalpa Shah

Joshua D White

Lee C Burnes

Steve Saeed Khalaj

Martha Lillian Tate

Shyamant Ramana Sastry

Jeremy Ollerenshaw

Thomas D Mina

Elliot Blake Bourgeois

Sara Kebede

Wanzhan Liu

Roger Dillard Massengale

Kaiyuan Yang

Tyler West Crone

Shawn Jeffery Sullivan

Martin S Shamis

Joseph DiPietro

James F Tassitano

Karl Thomas Bjurbo

Craig F Steinman

Matthew John Valaskey

Carolyn Y Sargent

Chris Zobkiw

David T Curd

Todd Hanson

Leah Roldan

Nicole Y Dumas

WonYeong Sohn

Skyler Canute

Gleb Klimovitch

Daniel Oster

Carolyn Yeago Sargent

Joseph Dipietro

Shyamant R Sastry

Elliot B Bourgeois

Nicole Dumas

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

Device and method to selectively and reversibly modulate a nervous system structure to inhibit pain

A system and method for locating a target nerve associated with a facet joint via nerve stimulation and monitoring of electrical muscle activity in a multifidus muscle adjacent the target nerve are described. The system includes a probe housed within a cannula and comprising a probe electrode; a recording electrode for monitoring electrical muscle activity in a medial fascicle of the multifidus muscle; a signal generator; and a controller coupled to the probe electrode and recording electrode. The controller delivers a nerve stimulation from the signal generator to the nerve via the probe electrode and monitors electrical muscle activity in the medial fascicle via the recording electrode. The probe's proximity to the nerve is determined by the electrical muscle activity in the medial fascicle elicited as a result of the nerve stimulation, where the controller provides feedback to a user to guide placement of the probe adjacent the nerve.

EMG guidance for probe placement, nearby tissue preservation, and lesion confirmation

A method of rapid frequency cycling during electrical stimulation according to an embodiment may include determining, by a controller of an electrical stimulation system, a plurality of frequency band groupings of discrete frequency bands of an electrical stimulation signal having a frequency range, wherein each frequency band grouping includes at least one discrete frequency band, wherein a corresponding current or voltage amplitude of the electrical stimulation signal is independently tuned within each discrete frequency band based on feedback received from a patient, determining, by the controller, a random sequence of the frequency band groupings of the plurality of frequency band groupings, generating, by at least one signal generator controlled by the controller, the electrical stimulation signal according to the determined random sequence of the frequency band groupings, and delivering the generated electrical stimulation signal through an electrode array to the patient to provide therapy to the patient.

Rapid frequency cycling during electrical stimulation

An electrical stimulation system for delivering spatially random electrical stimulation to a patient through an electrode array according to one embodiment includes an electrode array comprising a plurality of electrodes spaced apart from one another, a signal generator electrically coupled to the electrode array and configured to deliver an electrical stimulation signal, and a controller comprising a processor and a memory having a plurality of instructions stored thereon that, in response to execution by the processor, causes the controller to randomly select an electrical configuration from the plurality of electrodes of the electrode array by randomly selecting a first set of electrodes of the plurality of electrodes to function as electrical sources and a second set of electrodes of the plurality of electrodes to function as electrical sinks, and to instruct the signal generator to deliver the electrical stimulation signal to the patient via the randomly selected electrical configuration.

Electrode array for spatially random electrical stimulation

The present disclosure is directed to a system and method modulating targeted neural and non-neural tissue of a nervous system for the treatment of head-and-face pain. Electrical stimulation is delivered transcutaneously to the treatment site that modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting nervous signaling and the perception of pain.

Device and method to modulate a nervous system structure to non-invasively and non-destructively inhibit nervous signaling

A tubing assembly for use with an electronic catheter guidance systems is provided and includes a catheter and a stimulation electrode assembly, and an electrical connection for delivering a stimulation waveform to the stimulation electrode assembly. The catheter extends in a longitudinal direction and has a proximal end and a distal end that define a lumen therebetween. Further, the catheter is configured for placement within a patient's digestive tract. The stimulation electrode assembly is configured to deliver an electrical stimulation to tissue. A catheter guidance system and method for accurately placing a catheter in the digestive tract are also provided.

System and method for muscle stimulation and/or impedance measurement to verify proper tube placement

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neutral- and non-neural tissue of the nervous structure, inhibiting the perception of pain while preserving other sensory and motor function, and proprioception.

Device and method to selectively and reversibly modulate a nervous system structure to inhibit the perception of pain

A method of providing electrical stimulation therapy to a patient according to one embodiment includes generating an un-tuned electrical noise signal by at least one noise generator, partitioning the un-tuned electrical noise signal into a plurality of discrete frequency bands having corresponding bandwidths, delivering the un-tuned electrical noise signal through one or more electrodes to the patient to target the patient's central or peripheral nervous system, adjusting, for each of a plurality of selected frequency bands, an amplitude of the voltage or current of the un-tuned electrical noise signal within a corresponding frequency band to generate an adjusted electrical stimulation signal based on feedback received from the patient, wherein the adjusted electrical stimulation signal includes a plurality of local maxima and a plurality of local minima, and delivering the adjusted electrical stimulation signal through the electrodes to provide electrical stimulation therapy to the patient.

Tunable electrical noise signal technologies

The present invention is directed to a system and method for adaptive multivariate control for performing a radiofrequency (RF) ablation procedure with an energy delivery device. The system includes an energy source for delivering energy to a patient's body; one or more energy delivery devices; two or more sensors for measuring at least two factors related to an ablation procedure, respectively; and at least one processor. The method includes steps of: measuring at least two factors related to an ablation procedure; determining a first operating threshold based, at least in part, on a first factor; controlling an energy delivery device based on the first operating threshold to create a lesion at the target site within the patient; determining a second operating threshold based, at least in part, on a second factor; switching control of the energy delivery device from the first factor to the second factor; and controlling the energy delivery device based on the second operating threshold to create a lesion at the target site within the patient. The present invention is also directed to a RF probe configured to be used with the adaptive multivariate control system and method to perform RF ablation procedures.

Radiofrequency probe, system, and method for adaptive multivariate control of an ablation procedure

A method for identifying and treating a neural pathway associated with chronic pain via nerve stimulation and brain wave monitoring of a mammalian brain is described. The method includes positioning a probe to stimulate a target nerve, wherein the target nerve is suspected of being a source of chronic pain; delivering a first nerve stimulation from the probe to the target nerve, wherein the first nerve stimulation is sufficient to elicit a chronic pain response in the brain; and monitoring for evoked potential activity in the brain as a result of the first nerve stimulation. The method can also include delivering second and third nerve stimulations to confirm the correct identification of the neural pathway and to treat the chronic pain, respectively. A system and apparatus for performing a procedure to identify and treat a nerve that is the source of chronic pain are also described.

Method and system for identification of source of chronic pain and treatment

A method of providing therapy to a patient according to one embodiment includes partitioning a frequency range into a plurality of discrete frequency bands with each having a corresponding bandwidth, generating a composite electrical signal based on a plurality of periodic signals, wherein each periodic signal has a frequency within a corresponding frequency band of the plurality of discrete frequency bands, delivering the composite electrical signal through one or more electrodes to the patient to target at least one of neural tissue or non-neural tissue of the patient, adjusting an amplitude of one or more of a voltage or a current of the composite electrical signal within a selected frequency band of the plurality of discrete frequency bands to generate an adjusted signal based on feedback received from the patient, and delivering the adjusted electrical signal through the one or more electrodes to provide therapy to the patient.

Adjustable random electrical stimulation technologies

A method of providing therapy to a patient according to one embodiment includes generating an electrical noise signal by at least one noise generator controlled by a controller of a tunable noise system, partitioning the electrical noise signal into a plurality of discrete frequency bands, each of the discrete frequency bands having a corresponding bandwidth, delivering the electrical noise signal through one or more electrodes to the patient to target at least one of neural tissue or non-neural tissue of the patient, adjusting an amplitude of one or more of a voltage or current of the electrical noise signal within a selected frequency band of the plurality of discrete frequency bands to generate an adjusted electrical signal based on feedback received from the patient, and delivering the adjusted electrical signal through the one or more electrodes to provide therapy to the patient.

A multi-headed catheter for fluid delivery and a method of placing a multi-headed catheter for fluid delivery are provided. The multi-headed catheter includes a first tube extending along an axis, wherein the first tube has at least one exit hole provided at a distal end of the first tube to define a perfusion section of the first tube; and a second tube extending along the axis, wherein at least a portion of the second tube is disposed within the first tube, wherein the second tube has at least one exit hole provided at a distal end of the second tube to define a perfusion section of the second tube. The distal end of the second tube is configured to exit said first tube at an opening provided along a wall of the first tube. The perfusion sections of the first tube and the second tube can be independently placed to deliver fluid to distinct anatomical areas within a surgical wound site.

Multi-headed catheter for fluid delivery

The present disclosure is directed to a portable system and method for modulating targeted neural and non-neural tissue of a nervous system to block nerve conduction for the treatment of pain. A high-efficiency portable electrical stimulation system is provided that allows a user to carry the system and move around freely while continuously receiving therapy. The electronic control system is configured to deliver high-frequency electrical stimulation at a therapeutic level, for an intended duration (e.g., up to 24 hours or more) at a manageable and/or comfortable weight for a person, to the target nerve.

Portable electrical stimulation system and method

Growing community of inventors

Alpharetta, GA, United States of America

Eric Anthony Schepis