University of Pittsburgh

Ebb Therapeutics, Inc.

Cerêve, Inc.

Eric A Nofzinger

Jeffrey John Schirm

Robert E Tucker

Damian F Rippole

Craig B Reynolds

Methods, systems and devices for reducing anxiety, including increasing relaxation and/or calm. In some variations these methods may include reducing anxiety, increase relaxation and/or calm by non-invasive temperature regulation of the frontal cortex prior to and/or during sleep. The subject may have an anxiety disorder, or may not have a diagnosed anxiety disorder.

Noninvasive, regional brain thermal stimulation for inducing relaxation

Apparatuses and methods for treating neurological and/or neuropsychiatric disorders are by application of thermal energy to the patient's forehead region, for example, by maintaining a target temperature or temperature range to the forehead of a patient for a time period. In particular, described herein are regional brain cooling mechanisms to treat neuropsychiatric disorders such as depression, anxiety, and autism.

Noninvasive, regional brain thermal stimuli for the treatment of neurological disorders

Methods, systems and devices for treating headaches, including migraines. In some variations these methods may include enhancing sleep, including enhancing the quality of sleep, reducing sleep onset time, increasing total sleep time, treating insomnia, and/or treating other neurological disorders by non-invasive temperature regulation of the frontal cortex prior to and/or during sleep.

Noninvasive, regional brain thermal stimuli for the treatment of migraine

Apparatuses and methods to enhance sleep, reduce sleep onset latency, extend sleep duration and/or increasing the duration of deeper sleep stages relative to stage 1 sleep. In general, these apparatuses and methods apply and maintain one or more target 'warm' temperatures to a subject's forehead for a time period. The target temperature may be between 25&#xb0; C. and 42&#xb0; C. The target temperature may be a fixed amount greater than ambient temperature. The time period may be a fixed time period or a variable time period. These methods and apparatuses may limit the application of thermal energy to the subject's forehead region.

Apparatus and method for modulating sleep

Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to and/or during sleep to enhance sleep, which may be particularly beneficial to treat insomnia.

Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia

A method and device for treating neurological disorders involving the application of noninvasive, regional brain thermal stimulation to a region of a patient's head associated with a subject neurological disorder. The brain thermal stimulation method and device alters the brain function in the region of the brain underlying the region of the patient's head to which the brain cooling is applied. The method can also include the steps of adjusting the temperature and timing of the thermal stimulation process to optimize the impact on the subject disorder. The brain thermal stimulation device is comprised of a localized means for cooling or warming a desired region of a patient's brain.

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Allison Park, PA, United States of America

Eric A Nofzinger