Kinnate Biopharma Inc.

Amitech Therapeutic Solutions, Inc.

Other

Samumed, LLC

Eric A Murphy

Toufike Kanouni

Stephen W Kaldor

John S Tyhonas

Lee Daniel Arnold

Robert Steven Kania

Jason M Cox

Lee D Arnold

John Hood

David A Cheresh

Kimmo Koivu

Randall Weselake

Vishal Deshmukh

Eric Martin

Aleksandra Franovic

Richard Thomas Williams

Ken Kobayashi

Rodrigo Siloto

Nichol L G Miller

Qin Liu

André Laroche

Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.

Treatment of cancer with a RAF inhibitor

Provided herein are inhibitors of receptor tyrosine kinase effector, RAF, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Inhibtors of RAF kinases

Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Inhibitors of cyclin-dependent kinases

Inhibitors of RAF kinases

Provided herein are heteroaryl inhibitors of fibroblast growth factor receptor kinases, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Inhibitors of fibroblast growth factor receptor kinases

This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.

Methods of using indazole-3-carb oxamides and their use as Wnt/B-catenin signaling pathway inhibitors

Provided herein are compounds useful for kinase inhibition.

Heterocyclic compounds useful for kinase inhibition

The present invention is directed to methods and compositions for suppressing lymphangiogenesis, angiogenesis and/or tumor growth. The methods comprise contacting the tumor with a compound that (i) stabilizes a protein kinase in the inactive state and (ii) is not an ATP competitive inhibitor of the protein kinase in the active state.

Therapeutic methods and compositions involving allosteric kinase inhibition

The invention relates to isolated diacylglycerol acyltransferases and polynucleotide sequences encoding the DGAT enzymes; polynucleotide constructs, vectors and host cells incorporating the polynucleotide sequences; and methods of producing and using same. Also provided are transformed cells and transgenic plants, especiallyplant, with enhanced oil accumulation and quality.

Diacylglycerol acyltransferases from flax

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Encinitas, CA, United States of America

Eric A Murphy