Monsanto Technology LLC

Eric A Haupfear

Eduardo Aurelio Casanova

David R Eaton

Henry H Chien

Peter E Rogers

James P Coleman

David Z Becher

Stephen D Prosch

Donald D Soleta

Walter K Gavlick

Robert E Byrd

Mark D Scaia

Kenneth S Meyer

William B Hooper

Samuel J Tremont

Juan Pedro Arhancet

Jerry R Ebner

Patrick J Lennon

Jerald D Heise

Michael Rogers

Mark A Leiber

Lowell R Smith

Michael E Seitz

William A Scholle

Amy L Jorgenson

Serge G Wolfson

Bart Roose

Karen A Wittler, Legal Representative

Roger J Hoekstra

Philip H Brodsky

Joseph A Schaper

Alfredo Oba

Carl Mumford

Oliver Lerch

Leonard Aynardi

John Wagenknecht

This invention relates to the preparation of N-(phosphonomethyl)glycine ('glyphosate') from N-(phosphonomethyl)iminodiacetic acid ('PMIDA'), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.

Control of N-(phosphonomethyl)iminodiacetic acid conversion manufacture of glyphosate

This invention relates to the preparation of N-(phosphonomethyl)glycine ('glyphosate') from N-(phosphonomethyl)iminodiacetic acid ('PMIDA'), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content. One such method involves obtaining a series of Fourier transform infrared (&#x201c;FTIR&#x201d;) analyses of the PMIDA content of the aqueous reaction medium or a sample thereof during the course of the reaction. From a plurality of FTIR analyses, a projection is made of the batch reaction time or continuous oxidation residence time within the oxidation reaction zone at which a target conversion or end point may be anticipated to be attained or is attained.

Control of n-(phosphonomethyl)iminodiacetic acid conversion in manufacture of glyphosate

Control of N-(phosphonomethyl)iminodiacetic acid conversion in manufacture of glyphosate

This invention relates generally to improved methods and herbicidal glyphosate compositions for use in controlling the growth of weeds and unwanted vegetation, and particularly for use in controlling weeds in a crop of transgenic glyphosate-tolerant cotton plants by over-the-top, foliar application of a herbicidal glyphosate formulation.

Mitigating necrosis in transgenic glyphosate-tolerant cotton plants treated with herbicidal glyphosate formulations

N-phosphonomethylamines are produced by reaction of an amine substrate with a halomethylphosphonic acid or salt thereof, a hydroxymethylphosphonic acid or salt thereof, or a dehydrated self-ester dimer, trimer or oligomer of hydroxymethylphosphonic acid. Among the products that may be prepared according to the process are N-phosphonomethylaminocarboxylic acids such as (e.g.) glyphosate, N-phosphonomethylaminoalkanols such as (e.g.) hydroxyethlaminomethylphosphonic acid, and N-acylaminomethylphosphonic acids such as (e.g.) N-carbamylaminomethylphosphonic acid. Certain reactions are conducted with a substantial excess of amine reactant in order to drive the conversion while avoiding excessive formation of bis(N-phosphonomethyl)amine by-products. Other reactions use a secondary amine substrate (such as iminodiacetic acid) and can be conducted at substantial equimolar ratios of halomethylaminomethylphosphonic acid or hydroxyaminomethylphosphonic acid to secondary amine reactant without significant formation of bis(phosphonomethyl)amine by-products. Further disclosed is a process for the preparation of hydroxymethylphosphonic acid self-ester dimers, trimers and oligomers by azeotropic dehydration.

Process for the preparation of N-phosphonomethylglycine and derivatives thereof

An improved process for recovering a crystalline product (particularly an N-(phosphonomethyl)glycine product) from a solution comprising both a product subject to crystallization and undesired impurities is provided.

Process for recovering a crystalline product from solution

This invention generally relates to processes for recovering solubilized noble metals from aqueous process streams, in particular, aqueous process streams generated in the preparation of an N-(phosphonomethyl)glycine product, for example, by noble metal-catalyzed oxidation of an N-(phosphonomethyl)iminodiacetic acid substrate. The process includes contacting the aqueous process stream with a noble metal adsorption media such as an ion exchange resin to remove solubilized noble metal from the process stream.

Recovery of noble metals from aqueous process streams

This invention generally relates to liquid phase oxidation processes for making N-(phosphonomethyl)glycine (also known in the agricultural chemical industry as glyphosate) and related compounds. This invention, for example, particularly relates to processes wherein an N-(phosphonomethyl)iminodiacetic acid (NPMIDA) substrate (i.e., N-(phosphonomethyl)iminodiacetic acid, a salt of N-(phosphonomethyl)iminodiacetic acid, or an ester of N-(phosphonomethyl)iminodiacetic acid) is continuously oxidized to form an N-(phosphonomethyl)glycine product (i.e., N-(phosphonomethyl)glycine, a salt of N-(phosphonomethyl)glycine, or an ester of N-(phosphonomethyl)glycine). This invention also, for example, particularly relates to processes wherein an N-(phosphonomethyl)iminodiacetic acid substrate is oxidized to form an N-(phosphonomethyl)glycine product, which, in turn, is crystallized (at least in part) in an adiabatic crystallizer.

Reaction systems for making N-(phosphonomethyl) glycine compounds

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St. Charles, MO, United States of America

Eric A Haupfear