Thermospectra

Electronic Biosciences, Inc.

Compumed, Inc.

Eric A Duff

Andrew Dennis Hibbs

Xiaoli Bi

Brent J Liu

Dale D Thayer

David Edelstein

Hyeonjoon Shim

Philip Bowles

An electrolytic sensing system for measuring a blocking signal allows for controlled translocation of a molecule, such as DNA, through a fluid channel. A substantially constant electric field supplied by a DC source is applied across the fluid channel and induces translocation of the molecule within the system. An oscillating electric parameter (e.g. current or voltage) supplied by an AC source is also applied across the fluid channel as a means for measuring a blocking signal. The substantially constant electric field can be altered to provide more detailed control of the molecule and, optionally, run a select portion of the molecule through the channel multiple times to provide numerous signal readings. A temperature control stage cools the system, providing further control of molecule translocation. A modified or non-modified protein pore may be utilized in the fluid channel. The system allows for long DNA strands to be sequenced quickly without amplification.

Controlled translocation of a polymer in an electrolytic sensing system

An automatic segmentation module with an open architecture that automatically generates a contour of a target bone based on a digital image. In one embodiment, the digital image can include an extremity, such as a hand with three digits and a calibration wedge. The automatic segmentation module receives the digital image as an input, and automatically segments the target bone by utilizing an object-oriented approach. This approach extracts intermediate target objects and uses these intermediate target objects to refine or limit the search space in order to extract the final target object.

Method for automatically segmenting a target bone from a digital image

A method and apparatus are provided for imaging obscured areas of a test object. The apparatus includes an x-ray source having a cathode for producing a steerable electron beam. A controller directs the electron beam to predetermined locations on a target anode. The user may flexibly select appropriate predetermined positions. The predetermined locations may be obtained from the geometry of an obscuration. A detector receives x-rays that are transmitted through the test object from each of the predetermined locations, and produces images corresponding to each of the predetermined locations. The images are digitized and may be combined to produce an unobscured image of a region of interest.

Method and apparatus for imaging obscured areas of a test object

A calibration system having a radiation source that generates the beam of radiation along the angular directions .theta., .phi.. A first reference element which is separated from the radiation source by a distance of approximately Z.sub.1 is then exposed to the beam of radiation. A second reference element is also present which is separated from the first reference element by a predetermined distance H and is exposed to the beam of radiation. An image detector produces images of the first and second reference elements, wherein the images are separated from each other by a distance R and angle .phi.. The device further includes an angle measurement device that calculates .theta. from the values of Z.sub.1 and H. A position measurement device having first and second sources of radiation that generate respective first and second beams of radiation directed at angles .theta..sub.1, .phi..sub.1, and .theta..sub.2, .phi..sub.2 respectively, toward an object of interest. An image detector is provided for producing 1) a first image of the object of interest formed by the first beam of radiation and 2) a second image of the object of interest formed by the second beam of radiation and that is separated from the first image by a distance L. A coordinate device then determines the coordinate of the object of interest from the values of .theta..sub.1, .theta..sub.2 and L.

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San Diego, CA, United States of America

Eric A Duff