Daiichi Sankyo Company, Limited

Smk Corporation

Peptidream Inc.

Eri Otsuka

Takahiro Yamaguchi

Hideki Kubota

Akihiro Furukawa

Patrick Reid

Yutaka Mori

Osamu Kamishima

Hironao Saito

Tsubasa Hayase

Kumiko Kataoka

Yutaka Ishigai

Hiroshi Ijiri

Provided is a compound that can promote angiogenesis by inhibiting the function of TSP1, and is useful for the treatment or prophylaxis of diseases such as critical limb ischemia. Specifically provided is a macrocyclic polypeptide represented by formula (I) [wherein A is selected from the linking groups Ato A; Xis a residue of an aliphatic amino acid, an aromatic amino acid, a basic amino acid, a neutral amino acid, or an acidic amino acid, or is absent; Xis a residue of an aromatic amino acid or a neutral amino acid; Xis a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid; Xis Ser, Thr, Ala, orS; Xis Gly or Ser; Xis a residue of a basic amino acid or a neutral amino acid; Xis a residue of a neutral amino acid or an acidic amino acid; Xis a residue of an aromatic amino acid; Xis a residue of an aliphatic amino acid, a neutral amino acid, or an aromatic amino acid; Xis a residue of a basic amino acid, an aliphatic amino acid, an aromatic amino acid, or a neutral amino acid; Xis a residue of an aromatic amino acid; and Xis a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid], or a pharmacologically acceptable salt thereof.

Thrombospondin 1-binding peptide

Remote controller

Growing community of inventors

Tokyo, Japan

Eri Otsuka