Treventis Corporation

Denovamed Inc.

Denouamed, Inc.

Erhu Lu

Fan Wu

Christopher J Barden

Donald F Weaver

Mark Hadden

Thomas Kuchurean Wood

Mark A Reed

Michael D Carter

Shengguo Sun

Scott C Banfield

Arun Yadav

Sheila Marie H Jacobo

Fuye Gao

Thomas K Wood

Sheila Marie Jacobo

Compounds or pharmaceutical acceptable salts thereof of Formula (I), in which RM have the meaning described herein and pharmaceutical compositions thereof useful as antimicrobial and/or adjuvant: 

Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial

In general, among other things, compounds of Formula I are provided: in which Ris e.g., 4-(pyrrolidin-1-yl)piperidin-1-yl, N-methyl-3-(pyrrolidin-1-yl)propan-1-amino, N,N,N-trimethylpropane-1,3-diamino, N,N-dimethylpiperidin-4-amino, 3-(pyrrolidin-1-ylmethyl)azetidin-1-yl, 3-(pyrrolidin-1-ylmethanon)azetidin-1-yl, or 3-(morpholin-1-ylmethyl)azetidin-1-yl; Ris, e.g., phenyl optionally substituted with one or more substituents; and Rand Rare each independently hydrogen or alkyl. Methods of treatment are also provided.

Anti-amyloid compounds containing benzofurazan

Among other things, in general, antimicrobial and/or adjuvant compounds are provided according to Formula Ia: (Ia) in which E and R1-11 have the meanings described herein; and prodrugs and pharmaceutically acceptable salts thereof. Other formulae and methods of use are also provided. 

Antimicrobial/adjuvant compounds and methods

The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, A&#x3b2; protein or &#x3b1;-synuclein protein aggregation.

Compounds and methods for treating protein folding disorders

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Toronto, Canada

Erhu Lu