Hoechst Aktiengesellschaft

Erhardt Winkelmann

Wolfgang Raether

Akhileswer Sinharay

Ulrich Gebert

Hans Militzer

Heinrich Rolly

Wolfgang Baether

New 1-methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles are disclosed as well as a process for their manufacture. The new compounds are suitable for the treatment of protozoal diseases and show a marked activity against helminths, ectoparasites and ticks.

1-Methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles

Novel compounds of anthraquinone-bis-amidines are prepared which are suitable for combating diseases caused by trichomonads.

Anthraquinone-bis-amidines and process for preparing them

New (1-alkyl-5-nitro-imidazolyl-2-alkyl)-heteroaryl compounds are disclosed as well as a process for their manufacture. The new compounds are effective against pathogens, such as bacteria and protozoa, as well as against fungi.

Antiprotozoal(1-alkyl-5-nitro-imidazolyl-2-alkyl)-pyridazines

Certain 1-methyl-2-(substituted thiomethyl)-5-nitro-imidazoles are described as well as a process for their manufacture. The compounds are suitable for the treatment of protozoal diseases, especially of trichomoniasis and of fungus diseases, especially dermatomycoses.

1-Methyl-2-(substituted thiomethyl)-5-nitro-imidazoles

The invention provides 1-methyl-2-(pyridyl-oxymethyl)-5-nitro-imidazoles and processes for preparing them. The compounds are useful in the therapy of diseases provoked by protozoa.

1-Methyl-2-(pyridyl-oxymethyl)-5-nitro-imidazoles

1-Methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles and a process for preparing them are disclosed. The compounds of the invention are suitable for the treatment of protozoal diseases caused in humans and animals and of bacteria and fungi.

1-Methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles and process for their

1-Alkyl-2-(phenoxymethyl)-5-nitro-imidazoles are described as well as a process for their manufacture. The compounds are active against trichomonads and amoebae and are especially suitable for the treatment of Fluor genitalis.

1-Alkyl-2-(phenoxymethyl)-5-nitro-imidazoles and process for their

Novel 5-cyano-thiophen-2-aldehyde-isothiosemicarbazones are described as well as a process for their manufacture. These compounds are active against viruses and therefore suitable for the prophylaxis and therapy of corresponding infections in humans and animals.

5-Cyano-thiophen-2-aldehyde-isothiosemicarbazones and process for

New 1-alky-2-(pyridyl-sulfinylmethyl)-5-nitro-imidazoles and 1-alkyl-2-(pyridyl-sulfonylmethyl)-5-nitro-imidazoles are described according to the formula I ##STR1## in which R stands for a methyl, ethyl or hydroxyethyl group and Z stands for a --SO-- or --SO.sub.2 -- group and the pyridine ring is linked to the sulfinyl or the sulfonyl group in 2, 3 or 4 position as well as a process for their manufacture. The novel compounds have a pronounced activity against protozoae, especially trichomonads and amebae.

Composition for and method of treating diseases caused by protozoa

New (1-alkyl-5-nitro-imidazolyl-2-alkyl)-heteroaryl compounds and process for their manufacture are described. The new compounds are well compatible and are effective against bacteria and protozoa as well as against fungi. They are especially active against trichomonads and amebae.

(1-Alkyl-5-nitro-imidazolyl-2-alkyl)-heteroaryl compounds and process

Antiprotozoal (1-alkyl-5-nitro-imidazolyl-2-alkyl)-pyrimidines

(1-ALKYL-5-NITRO-IMIDAZOLYL-2-ALKYL)-HETEROARYL COMPOUNDS AND A PROCESS FOR THEIR MANUFACTURE ARE DESCRIBED. The new compounds are well compatible and are effective against bacteria and protozoa as well as against fungi. They are especially active against trichomonads and amebae.

(1-Alkyl-5-nitro-imidazolyl-2-alkyl)-heteroaryl compounds

This invention provides 1-alkyl-2-(pyridylthiomethyl)-5-nitro-imidazoles and 1-alkyl-2-(N-oxy-pyridylthiomethyl)-5-nitro-imidazoles of the formula ##SPC1## In which R is methyl, ethyl or hydroxyethyl and the pyridyl and N-oxy-pyridyl group is linked in 2-, 3- or 4-position to the sulfur atom, as well as process for the manufacture of these compounds. The novel compounds are suitable for the treatment of protozoal diseases in mammals.

Composition for and method of treating disease caused by protozon

1,4-BIS-5'-NITROIMIDAZOLYL-2'-METHYLENE-IMINO) PIPERAZINES OF THE FORMULA ##SPC1## In which R.sub.1 is hydrogen, methyl, ethyl or 2-hydroxyethyl and R.sub.2 is hydrogen or methyl, are prepared by reaction of 5-nitro-imidazolyl-2-aldehydes or the functional derivatives thereof with 1,4-diamino-piperazines. Pharmaceutical compositions containing these compounds for treating protozoal diseases and methods of treating protozoal diseases with these compounds are disclosed.

Pharmaceutical compositions containing

Bis-(1-alkyl-5-nitro-imidazolyl)-compounds as well as a process for their manufacture are described. The compounds are active against protozoal diseases.

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Kelkheim (Taunus), Germany

Erhardt Winkelmann