Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Memorial Sloan Kettering Cancer Center

Clexio Biosciences Ltd.

Erez Koren

Yechezkel Barenholz

Richard N Kolesnick

Itzhak Shalev

Mark Zamansky

The disclosure is directed to fibrous structures finished with active pharmaceutical ingredients, as well as methods of their manufacturer and use.

Finished fibrous structures and methods of their use and preparation

Based on the observation that the application of small amounts of exogenous acid sphingomyelinase to generate endogenous ceramide, or provision of exogenous long-chain natural C16-ceramide resulted in rapid translocation of vacuolar daunorubicin into the nucleus in multi-drug resistant (MDR) cells, the present invention relates to a nano-liposomal preparation that includes C16-ceramide. Exposure of MDR cells to the C16:0 ceramide-based nanoliposomes provide a mechanism to reverse MDR in chemoresistant cells and tumors, by inducing rapid translocation of chemotherapeutic agent from cytoplasmic vesicles to the nucleus.

Ceramide reversal of multi-drug resistance

Growing community of inventors

Ramat Hasharon, Israel

Erez Koren