Valtech Cardio Ltd.

Edwards Lifesciences Innovation (israel) Ltd.

Mitraltech Ltd.

Accurate Medical Therapeutics Ltd.

Cardiovalve Ltd.

Carevature Medical Ltd.

Argon Medical Devices Inc.

Cardiovale Ltd.

Edwards Lifesciences Innovation Ltd.

Eran Miller

Oz Cabiri

Tal Reich

Amir Gross

Yuval Zipory

Yossi Gross

Gil Hacohen

Yoseph Weitzman

Iftah Beinart

Tal Sheps

Yaron Herman

Nir Lilach

Michael Gabriel Tal

Eliahu Eliachar

Dmitry Golom

Gideon Meyer-Brodnitz

Ram Grossfeld

Francesco Maisano

Rotem Neeman

Tal Hammer

Arnon Mosaiuf

Aviram Baum

Yosef Gross

Meir Kutzik

Natalia Kruglova

Uriel Aba Pomerantz

Ely Ashkenazi

David Skorohod

Arnon Mousaiuf

Osnat Harbater

Gili Hacohen

Aram Ayvazian

Tom Dagan

Nir Holtzman

Judy Cashdan

Nir Holzman

Gabriel Michael Tal

An embolization microcatheter for delivery of embolization beads to a target area, the embolization microcatheter including a proximal end and a distal end, the distal end terminating in an end opening sized and shaped to allow delivery of a suspension of the embolization beads, and a filter section located in proximity to the end opening of the distal end; the filter section including a large plurality of openings distributed circumferentially around a wall thereof, the filter section configured to allow an outflow of the suspension while preventing an outflow of the embolization beads.

Embolization catheter for reflux free delivery of microspheres

An implantable prosthetic device for repairing a native valve includes a first clip, a second clip, a first cord, and a second cord. The first clip has a first arm and a second arm and is moveable between an open position and a closed position. The second clip has a third arm and a fourth arm and is moveable between an open position and a closed position. The first cord is operatively coupled to the first clip for moving the first clip between the open and closed position. The second cord is operatively coupled to the second clip for moving the second clip between the open and closed position. The device is configured to clamp a first leaflet of the native mitral valve between the first arm and the second arm and to clamp a second leaflet of the native mitral valve between the third arm and the fourth arm.

Method and apparatus for repairing a heart valve

Embolization microcatheter for delivery of beads to peripheral vessels

An implant structure, comprises a body portion, a first adjusting mechanism, and a second adjusting mechanism. The body portion is configured to be secured within a heart of a patient. The first adjusting mechanism is coupled to a first portion of the body portion, and comprises a first ring that surrounds the first portion and is moveable with respect to the body portion. The second adjusting mechanism is coupled to a second portion of the body portion, and comprises a second ring that surrounds the second portion and is moveable with respect to the body portion. A first elongate tool is configured to remodel tissue of the heart by actuating the first adjusting mechanism. A second elongate tool is configured to remodel tissue of the heart by actuating the second adjusting mechanism.

Implant having multiple adjusting mechanisms

An anchor is shaped to define a helix. A deployment tool is reversibly coupled to the anchor, and includes a lance. The deployment tool is configured to transluminally advance the anchor to the heart, and to stabilize the anchor at the tissue by driving the lance into the tissue. The deployment tool is also configured to anchor the anchor to the tissue, for example, by driving the tissue-penetrating helix into the tissue while the anchor remains stabilized at the tissue by the lance in the tissue, and to subsequently retract the lance from the tissue while leaving the anchor anchored to the tissue. Other embodiments are also described.

Techniques for guide-wire based advancement of a tool

A surgical bone cutting device, including a handle configured to facilitate operation and control of said device by an operator, and an elongated hollow member extending from the handle, the hollow member having a proximal end and a distal end; wherein the hollow member includes an opening at the distal end thereof and a rotatable cutting element extending through the opening, and wherein the hollow member includes a first bend at the proximal end thereof, such that the part of the hollow member distal to the proximal bend is offset a central axis of the hand.

Surgical instrument with bended shaft

An embolization microcatheter having an elongated microcatheter body configured for passing therein a suspension of particles suspended in a suspension fluid; and a microcatheter head connected to a distal end of said microcatheter body and comprising a proximal head section and a distal head section, wherein the proximal head section includes a proximal wall forming a proximal section lumen, the proximal wall having a plurality of through-holes, wherein the distal head section includes a distal wall forming a distal section lumen, and a suspension delivery opening at a distal end of the distal end section; wherein the distal section is devoid of through-holes, and wherein each of the plurality of through-holes are shaped and/or sized to allow passage therethrough of the suspension fluid while blocking passage of the particles suspended therein.

Embolization microcatheter head having slitted pattern

An anchor of an implant is transluminally advanced to a heart of a subject, the anchor including a distal helical element, and a post extending proximally from the distal helical element. The implant is anchored to tissue of the heart by driving the distal helical element into tissue of the heart, and compressing a fabric tube against the tissue by moving an annular member, coupled to the post, toward the tissue such that the fabric tube becomes sandwiched between the annular member and the tissue. Other embodiments are also described.

Tissue anchor for heart implant

Devices, methods and kits for preventing or reducing non-target microparticles deposition and embolization, in conjunction with delivering microparticles (e.g., embolization material) via a blood vessel to a target bodily part. Applicable for entrapping infiltrated microparticles within heart right atrium. Entrapping device includes: filter; and filter collapsing mechanism sized for positioning in catheter lumen of a filter delivering catheter, and having proximal end actuatable from outside of subject. Filter configured for positioning within heart right atrium, for self-expanding and covering right atrium inlet opening, and configured, when expanded, to collect embolic material delivered to target organ and infiltrated into outflow vessel thereof draining to right atrium. Filter collapsing mechanism configured for collapsing, and being manipulated to form a pocket in filter, to entrap collected embolic material therein, and drawing filter with collected embolic material in pocket, into catheter lumen of filter delivering catheter.

Preventing non-target embolization

A first part of an annuloplasty structure is anchored to an annulus of a valve of a heart by using a driver to screw a tissue-coupling element of a first anchor into a first site of the annulus, such that the tissue-coupling element enters cardiac tissue in a direction parallel to a central longitudinal axis of the driver through the distal end of the anchor driver. The same is subsequently done for second and third parts of the annuloplasty structure using second and third anchors at second and third sites of the annulus,. Between anchors, the driver is retracted out of the heart. Subsequently, the valve is treated by reducing a distance between the first site and the second site, and a distance between the second site and the third site, by tightening a flexible and elongate contracting member of the annuloplasty structure.

Deployment techniques for annuloplasty structure

Systems and apparatuses herein include a longitudinal member having opposite first and second end portions, a tension of the longitudinal member being adjustable to repair an atrioventricular valve of the patient. A delivery tool can be configured to couple the first end portion of the longitudinal member to a first portion of heart tissue, couple the second end portion of the longitudinal member to the leaflet, adjust tension of the longitudinal member, assume a first diameter at a portion of the delivery tool that passes between the leaflets of the atrioventricular valve, during coupling of the first end portion of the longitudinal member to the first portion of heart tissue, and assume a second diameter that is smaller than the first diameter, at the portion of the delivery tool that passes between the leaflets of the atrioventricular valve, during adjusting of the tension of the longitudinal member.

Implantation of repair chords in the heart

An embolization microcatheter is configured to deliver embolization particles to a target area and minimize or prevent embolization of a non-target area. The microcatheter includes a section, located between the distal and proximal ends of the microcatheter, having a skeleton formed of braided wires and a polymeric layer intercalated into and/or overlaying the skeleton. This section includes a plurality of axial slits, each slit having a smallest cross-sectional dimension configured to prevent outflow of the embolization particles.

Embolization catheter with integral filter

A tissue-engaging element has a distal portion configured to engage a portion of tissue of the heart. A guide member is reversibly coupled to the tissue-engaging element. An elongate implant has a distal end and a proximal end, at least the distal end being slidably coupled to the guide member. A tool is slidable along the guide member distally toward the tissue-engaging element while (i) the tool is coupled to at least the distal end of the elongate implant, and (ii) the guide member is coupled to the tissue-engaging element, such that sliding of the tool along the guide member distally toward the tissue-engaging element while (i) the tool is coupled to at least the distal end of the elongate implant, and (ii) the guide member is coupled to the tissue-engaging element, slides at least the distal end of the elongate implant toward the tissue-engaging element.

Apparatus and method for guide-wire based advancement of an adjustable implant

Apparatus is provided, including an implant including a tissue-adjusting member including a longitudinal member, and a tissue anchor coupled to the tissue-adjusting member and configured to be anchored into the tissue of the patient. A tissue-coupling element is coupled to the longitudinal member. A delivery tool is reversibly couplable to the implant and is configured to deliver the implant to the tissue of the patient. The delivery tool includes an elongate shaft, a tissue-coupling-element holder coupled to a portion of the elongate shaft, the tissue-coupling-element holder being configured to hold the tissue-coupling element during delivery of the implant to the tissue of the patient, and an actuating element configured to rotate the tissue anchor so as to facilitate anchoring of the tissue anchor into the tissue of the patient while not rotating the tissue-coupling-element holder with respect to the shaft.

Systems and methods for tissue adjustment

A sheath is transluminally introduced a sheath into an atrium of a heart of a subject. A guide member is advanced out of the sheath and to a chorda tendinea of the heart, the guide member having a proximal portion that includes a longitudinal element, and a distal portion that includes a helical chord-engaging element. The chord-engaging element is wrapped around the chorda tendinea. While the chord-engaging element remains wrapped around the chorda tendinea, (i) the chord-engaging element is slid over the chorda tendinea toward a papillary muscle that is coupled to the chorda tendinea; and (ii) subsequently, a tool is moved out of the sheath and toward the papillary muscle by sliding the tool along the longitudinal element. Other embodiments are also described.

Techniques for guided advancement of a tool

Growing community of inventors

Moshav Beit Elazari, Israel

Eran Miller