Tel Aviv University

Kimron Veterinary Institute

Columbia University

The State of Israel, Ministry of Agriculture & Rural Developement, Kimron Veterinary Institute

Eran Bacharach

Avi Eldar

Walter Ian Lipkin

Thomas Briese

Nischay Mishra

Marcelo Ehrlich

Ben Shai

Oded Danziger

The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.

Tilapia virus and uses thereof

The present invention relates to a unique oncolytic virus, Epizootic Hemorrhagic Disease virus-Tel Aviv University (EHDV-TAU), and to methods and pharmaceutical compositions comprising thereof for preventing or treating cancer exhibiting an alteration in interferon signaling and/or the innate immune antiviral response.

Epizootic hemorrhagic disease virus&#x2014;tel aviv university (EHDV-TAU)&#x2014;oncolytic virus for treating cancer

The invention is directed to isolatedLake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.

The present invention relates to vaccine compositions comprising attenuated strain of Tilapia Lake Virus (TiLV) for protecting tilapia fish against infection by (TiLV). The invention also relates to methods for using the vaccines to protect tilapines from TiLV-induced disease.

Tilapia lake virus vaccines

The present invention relates to vaccine compositions comprising attenuated strain of Tilapia Lake Virus (TiLV) for protectingfish against infection by (TiLV). The invention also relates to methods for using the vaccines to protect tilapines from TiLV-induced disease.

The present invention relates to vaccine compositions comprising attenuated strain ofLake Virus (TiLV) for protectingfish against infection by (TiLV). The invention also relates to methods for using the vaccines to protect tilapines from TiLV-induced disease.

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Tel Aviv, Israel

Eran Bacharach