Other

Dr. L. Zambeletti Spa

Officina Terapeutica Italiana O.t.i. Laboratorio Biologico S.p.a.

Laboratori Biochimici Fargal-pharmasint S.p.a.

Eraldo Antonini

Luigi Molteni

Gian Piero Vercesi

This invention relates to aseries of tripeptides of the general formula: ##STR1## wherein R = -- H, COCH.sub.3, alkyl

Tripeptides, their esters and amides, and anti-ulcera activity thereof

A composition for the treatment of bacterial-intestinal infections, especially in infants, containing as an essential ingredient thereof, an effective amount of conalbumen.

Composition for the treatment of bacterial-intestinal infections

A process for extracting and isolating from snake venoms the enzymatic component having 'in vitro' coagulant activity and 'in vivo' anticoagulant activity from the other components having 'in vitro' coagulant activity and from the protein components, wherein the snake venom, dissolved in a medium suitable for chromatographic separation treatment is passed through a column filled with a solid support for selective absorption of said in vivo anticoagulant enzyme, not soluble in aqueous solvents, bound to a substratum or inhibitor of said enzyme, a first elution medium at pH 6-7 and molarity less than or equal to 0.05M is passed through said filling, wherein said venom has been introduced, the eluate is collected in subsequent portions until the elution of more than 95% of the protein components of the venom and an 'in vitro' coagulant fraction, different from that present in the second eluate are obtained, a second elution medium at a pH even greater than 9 and molarity greater than or equal to 0.3M is passed through, the eluate is collected in subsequent portions until the elution of the in vivo anticoagulant enzyme absorbed in the column, together with less than 5% of protein components are obtained, anticoagulant pharmacological preparation obtained according to the above process.

Process for the extraction of components having anticoagulant activity

A method for isolating conalbumin as used for strongly interbinding metals, such as iron and copper. According to the method, the white of egg is caused to pass through chelating ions coordinated to metal ions of the transition group at a pH buffered between 3 and 6. Then the mass is caused to pass through an active component for the conalbumin-metal complex, the conalbumin being finally isolated therefrom.

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Rome, Italy

Eraldo Antonini