Duke University

The United States Government as Represented by the Department of Veterans Affairs

Ephraim L Tsalik

Geoffrey S Ginsburg

Christopher W Woods

Ricardo Henao Giraldo

Joseph E Lucas

Rachel A Myers

Vance Fowler

Sun Hee Ahn

Thomas W Burke

Micah T McClain

The present disclosure provides methods and systems for processing a nucleic acid sample. The present disclosure also provides methods and systems for detecting (e.g., optically detecting) a pathogen in a sample. The methods provided herein may use nucleic acid amplification.

Methods and systems for processing a nucleic acid sample

The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided.

Gene expression signatures useful to predict or diagnose sepsis and methods of using the same

Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.

Biomarkers for the molecular classification of bacterial infection

Growing community of inventors

Cary, NC, United States of America

Ephraim L Tsalik