Abbott Diabetes Care Inc.

Therasense, Inc.

E. Heller & Company

Flexplay Technologies, Inc.

Synagile Corporation

Ephraim Heller

Adam Heller

Fredric C Colman

James L Say

Michael F Tomasco

Mark S Vreeke

Phillip John Plante

Yoram Gal

Behrad Aria

Keith A Friedman

Benjamin J Feldman

Fei Mao

Joseph A Vivolo

Rajesh Krishnan

Jeffery Van Funderburk

Michael V Pishko

Aria Behrad

John C Spiridigliozzi

Yannis Bakos

Erik Brynjolfsson

Paul O Haugsjaa

Steven DiIanni

Roger Bonnecaze

Karl Göran Westerberg

Steven Sitkiewitz

Bruce Rehlaender

Evangelos C Eleftheriou

Jeffrey V Funderburk

John Spiridiglozzi

The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.

Devices for the administration of pharmaceutical suspensions

Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of their use

A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

Small volume in vitro analyte sensor

An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

Analyte monitoring device and methods of use

Growing community of inventors

Oakland, CA, United States of America

Ephraim Heller