Bracco Imaging S.p.a.

Other

Enzo Terreno

Silvio Aime

Daniela Delli Castelli

Fulvio Uggeri

Franco Fedeli

Dario Livio Longo

Luciano Lattuada

Carlo Scolastico

Pierfrancesco Morosini

Leonardo Manzoni

Daniela Arosio

Giovanni Battista Giovenzana

Valentina Mainero

Alessandro Barge

Mauro Botta

Joseph Stancanello

Walter Dastrù

The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.

CEST systems exhibiting a concentration independent responsiveness

The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable stereoisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable stereoisomers in solution useful as concentration independent CEST responsive agents.

The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.

Integrin targeted synthetic ligands for diagnostic and therapeutic applications

Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).

Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for 'cest' applications

The present invention relates to a method for the in vivo, ex vivo, or in vitro determination of physical or chemical parameters of diagnostic interest by use of a slow tumbling paramagnetic agent that is responsive to changes of said physical or chemical parameter through changes in the R/Rratio allowing the determination of the said parameter in a manner that is independent on the actual agent concentration.

MRI contrast agents endowed with concentration independent responsiveness

An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated according to the magnetic responses of the selected location in a non-punctual agent range of frequencies including the agent frequency, and the reference value is calculated according to the magnetic responses of the selected location in a non-punctual reference range of frequencies including the reference frequency (with the reference range that is symmetric to the agent range with respect to the bulk frequency). Comparison means is then provided for calculating a parametric value for each selected location; the parametric value is calculated according to a comparison between the agent value and the reference value of the selected location.

MRI-CEST diagnostic technique based on non-punctual analysis

The invention concerns a method for obtaining diagnostic images of a human or animal body organ, region, fluid or tissue by using combined X-ray and/or Magnetization Transfer (MT) based MRI techniques and iodinated radiographic compounds as contrast agents, as well as improved Chemical Exchange dependent Saturation Transfer (CESDT or CEST) based MRI procedures in which a iodinated contrast agents is used for in vivo determining a physiological parameter of diagnostic interest.

Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics

A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.

Responsive paramagnetic MRI contrast agents

The invention relates to a method for the Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Imaging of a substrate molecule different from water wherein the NMR signal is enhanced by a reversible binding of the substrate molecule to a paramagnetic chelate complex, as well as to the use of a paramagnetic chelate complex in said method and the pharmaceutical composition for use therein.

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Bibiana, Italy

Enzo Terreno