Miles Laboratories, Inc.

Enrique Hong

Robert N Schut

Max E Safdy

Disclosed is the novel compound methyl 3-acetamido-2-(5-methoxyindol-3-yl) propanoate which is useful as an anti-hypertensive agent.

Methyl 3-acetamido-2-(5-methoxy-indol-3-yl) propanoate and hypotensive

Disclosed are compounds characterized by the structural formula: ##STR1## Various compounds circumscribed by the foregoing formula in which: R is H, CH.sub.3 or CH.sub.2 CH.sub.3,

3-Amino or amido-2-(1H-indol-3-yl) propanoic acid derivatives

The compounds having Formula I, ##STR1## wherein X is a fluorine or methoxy group, and R is a hydrogen or methyl group, such that R is hydrogen only when X is fluorine are novel. The compounds having Formula I and their acid addition salts are useful for the treatment of hypertension. Processes for the preparation of the compounds having Formula I and useful intermediates are described.

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Cerro San Francisco, Mexico

Enrique Hong