Epygon

Aorticlab Srl

Centre Hospitalier Universitaire De Saint-ÉTienne

Gem Srl

Myra Medical Sàrl

Aorticlab Italy Srl

Aorticlab Sarl

Enrico Pasquino

Marcio Scorsin

Franco Osta

Francesco Bonetti

Stefano Osta

Bernard Pain

Andrea Marchisio

Marco Vola

Sergio Casalegno

Marco Gard

Stefano Pasquino

Lorenzo Valerio

Enrico Fermi

Pietro Arru

Mario Di Cecio

Claudio Piccoli

Davide Benettin

Guido Bettoni

Giulia Parigi

Yi Peng Bai

Davide Gastaldin

Nicola Di Modugno

Lodovico Branchetti

An intra-vessel transcatheter filter device () designed to capture and remove emboli, thus preventing distal embolization, comprising: • a tubular filter () comprising a flexible porous material and defined by a distal element and a proximal element, namely a main body () and a funnel (); i. said main body () having a length adapted to extend within a suitable vessel zone; said main body () comprising: a) a distal end () that is adapted to be radially coupled with said zone and hermetically sealed to it when the device is in an active configuration, said distal end () being provided of selectively actionable closure means so that said distal end is designed to be open when the device is in an active configuration and closed before the device retraction, b) a proximal end (); ii. said funnel () forming an extension of said main body (), with the funnel base located at said proximal end (). • a support structure assembly () comprising: i. a supporting catheter () extending within said main body (), ii. one radially expandable distal structure () fixed to said distal end (), iii. one radially expandable proximal structure () positioned in correspondence of said proximal end (), said distal structure () and said proximal structure () being fixed at least in an end to said supporting catheter ().

Transcatheter anti embolic filter for arterial and venous vessels

Device for the treatment of tissue calcification, in particular aortic valve leaflets, characterized by the fact that it comprises a first ultrasound emission source that is adapted to provide ultrasound waves with MHz frequencies and a second ultrasound emission source that is adapted to provide ultrasound waves with KHZ frequencies, both MHz and KHz waves being used for the said treatment. The invention also includes a method for the treatment of tissue calcification that is characterized by the simultaneous use of ultrasound waves with MHz frequencies and ultrasound waves with KHz frequencies.

Device for the treatment of tissue calcification

Transcatheter delivery system for a self-expandable heart valve prosthesis () comprising a handle (), a hollow shaft () a distal tip () and an actuation mechanism for moving a valve prosthesis () towards said distal tip () or said handle (), said hollow shaft () being adapted to slidingly receive a compressed valve prosthesis (); the system being characterized by the fact that it includes a valve prosthesis crimping tool that comprises a hollow conical element (), a detachable transfer tube () and a pulling device (); said conical element () being adapted to let a valve prosthesis () in an expanded state enter the conical element () through its basis and enter said transfer tube () in a compressed state, said valve prosthesis () being pulled by said pulling device () when crossing said conical element () and entering said transfer tube (), said transferring tube () being adapted to be temporarily connected to said conical element ().

Delivery system for transcatheter prosthetic heart valves

Transcatheter device for the treatment of calcified native heart valve leaflets comprising an outer hollow shaft (), an inner hollow shaft () slidingly contained within said outer shaft () and an axle body () slidingly contained within said inner shaft (); wherein the device comprises a commissure debridement system (), located at the distal end of the axle body (), that is made of at least two radially expandable arms () that are adapted to be inserted in and aligned with native commissures.

Transcatheter device for the treatment of calcified heart valve leaflets

The invention concerns the treatment of bioprosthetic tissues a Cyclodextrin, preferably in association with Ethanol.

Product and method for the treatment of bioprosthetic tissues

Prosthetic heart valve leaflet with a fixed end and a free end characterized by the fact that it has a variable thickness.

Prosthetic heart valve leaflet with variable thickness

A transcatheter temporary valve prosthesis for blood vessel comprising an expandable support structure (&#x2033;), a valve (), a filter () and a conveyor (); said support structure (&#x2033;) forming a tubular shape when expanded, with a distal and a proximal end, said valve () being located at said distal end and said conveyor () extending within said support structure (), from said proximal to said distal end and including a central passage that is adapted to act as an introducer for other devices.

Transcatheter valve prosthesis for blood vessel

Electromagnetic (EM) tissue ablation device comprising an EM field generator unit, at least two coaxial elongated elements (i.e. an external one and an internal one) and a mechanism for varying the EM field, wherein said internal element is a part of said generator and said mechanism being adapted to vary the EM field for a specific tissue area.

Electromagnetic tissue ablation device

An expandable stent-valve has a stent component and a valve component, preferably an aortic valve component, a mitral valve component or a tricuspid valve component. The stent has, an outer surface area structured in a manner such that the surface area has a higher coefficient of friction between the outer surface and a duct wall than an untreated surface area of the stent component. The surface area is preferably structured with micro-incisions or micro-grooves.

Expandable stent-valve and method for manufacturing a stent

Atrio-ventricular valve stent () having a tubular shape, with a sub annular anterior side (), a sub annular posterior side () and sub annular lateral sides (), the sub annular anterior side () comprising a self-folding native leaflet engagement member (-) that forms a straight extension of said sub annular anterior side () when the stent () is collapsed and that is folded on itself when the stent () is in an expanded state; said engagement member (-) forming an integral part of the stent () and wherein each sub annular lateral side () is longer than said sub annular anterior side () when the stent () is in an expanded state.

Atrio-ventricular valve stent with native leaflet grasping and holding mechanism

A cardiac stent-valve (), preferably a mitral stent-valve, comprising a stent component () and a valve component (), wherein the stent component () comprises an inflow end () and an outflow end () and a wall between the inflow () and the outflow end (), and wherein the valve component () is made of one single leaflet (); the periphery of said single leaflet () being partially attached or attachable to the stent component () along at least fixation lines (), characterized in that said two fixation lines (') are at least partially inclined with respect to an annular plane of said valve perpendicular to a flow direction (A) through the stent-valve () and wherein the third fixation line (&#x2033;) runs parallel with respect to said plane.

Cardiac stent-valve and delivery device for such a valve

A prosthetic valve, preferably an expandable prosthetic valve, having a valve component (), preferably a mitral valve component, made of a single functional leaflet () wherein the prosthetic valve () comprises at least two tissue supports (&#x2033;&#x2033;) attachable to an inner surface () of a stent component (), wherein at least one tissue support (&#x2033;&#x2033;) comprises at least one attachment area (&#x2033;), at least a section of the attachment area extending essentially inwardly from the inner surface (), wherein said leaflet () is attached to at least one tissue support ('&#x2033;) at the section of said attachment area(s) (&#x2033;) such that the leaflet () is arranged between said attachment area(s) (&#x2033;) or integrally formed with one tissue support (&#x2033;&#x2033;) and attached to the second tissue support (&#x2033;&#x2033;) at the section of the attachment area(s) (&#x2033;).

Prosthetic monoleaflet valve and delivery device

Medical device for transcatheter heart valve repair comprising a grasping tweezer () and a plicating tweezer (), said grasping tweezer () being adapted to grasp a leaflet rim () and said plicating tweezer () comprising two rotatable flaps () and a central shaft () around which said flaps () may rotate in a 'butterfly manner', in such a way that the plicating tweezer () may adopt a closed or an open configuration. The invention also relates to a method for using this medical device.

Device and method for transcatheter heart valve repair under triangular resection technique

A device for transcatheter insertion into the aortic root at the sinotubular junction by a wire guide and a catheter for protecting surrounding tissues, the device including an assembly serving as a valvular embolic filter, configured to slide in a guided manner inside the catheter, the assembly configured to form, in the aortic root of an aorta, a safety enclosure ensuring a valve function and a protective function against embolic accidents, wherein the assembly includes, a tubular body, and a filtration and valve part configured to deploy outside the catheter or retract inside the catheter, wherein the tubular body is secured, at one end, to the filtration and valve part, wherein the filtration and valve part forms the valvular embolic filter and a temporary valve, wherein the filtration and valve part is configured to prevent regurgitation of blood when deployed outside the catheter for covering a native aortic valve with a seat secured in the aortic root at sinuses of valsalva without obstructing a blood flow.

Device for transcatheter insertion into the aortic root at the sinotubular junction

Heart valve prosthesis, comprising a ring-shaped supporting structure () to be anchored at the valve annulus, and a valve leaflet () supported by the supporting structure. The supporting structure comprises a support wall portion (), at which a root end () of the valve leaflet is connected, and a complementary wall portion () opposite the support wall portion, which supports a coaptation surface () adapted to be sealingly engaged by a free end () of the valve leaflet (), and extending in a direction parallel to the direction of movement of the free end () of the valve leaflet () at the coaptation surface (). The free end of the valve leaflet () is connected to the support wall portion or to the complementary wall portion by means of a traction member (), dimensioned in such a way that the free end () of the valve leaflet () is stopped at the coaptation surface.

Growing community of inventors

Savigny, Switzerland

Enrico Pasquino