Salix Pharmaceuticals, Inc.

Napo Pharmaceuticals, Inc.

Enoch Bortey

William Forbes

Kunal Merchant

Audrey Shaw

Pravin R Chaturvedi

Steven Row King

Lorin K Johnson

Pam Golden

Anthony Fodor

Craig Paterson

The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin. The instant application also provides methods for determining if a subject has a neurological condition or hepatic encephalopathy by determining the critical flicker frequency and/or the venous ammonia level of the subject at two or more time points. The invention further provides methods for treating these subjects.

Methods of treating hepatic encephalopathy

The present invention provides new methods and kits for treating IBS; treating IBS in females; treating IBS in older subjects; and treating IBS in non-white subjects.

Methods for treating irritable bowel syndrome (IBS)

The instant application provides methods of diagnosing and treating a subject having IBS. In certain embodiments, the methods also include diagnosing subjects who will respond to IBS treatment with rifaximin.

IBS microbiota and uses thereof

Treatment of traveler's diarrhea using in subjects having hepatic encephalopathy using gastrointestinal specific antibiotics is disclosed. One example of a gastrointestinal specific antibiotic is rifaximin.

Methods of treating traveler's diarrhea and hepatic encephalopathy

Presented herein are methods for treating diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. Treatment of diarrhea includes the treatment of the diarrhea as well as the pain, abdominal discomfort and other symptoms associated with diarrhea. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.

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Chapel Hill, NC, United States of America

Enoch Bortey