Boehringer Mannheim Italia

Boehringer Biochemia Robin S.p.a.

Ennio Cavalletti

Sergio Tognella

Odoardo Tofanetti

A Paul Krapcho

Miles P Hacker

Ferdinando C Giuliani

Roberto Assereto

Michele Tedeschi

Glutathione as chemoprotective agent

In the search for novel heteroanalogs of anthracenediones, 6,9-bis[(2-aminoethyl-amino]-benzo[g]isoquinoline-5,10-dione dimaleate (BBR 2778), was selected as the most promising compound. Toxicological studies indicate that BBR 2778 is not cardiotoxic.

6,9-bis[(2-aminoethyl) amino]benzo [g]isoquinoline-5,10- dione

Pharmaceutical compositions containing unit or separate dosages of 2.5 to 5 grams of reduced glutathione (GSH) and known anti-tumor agents, to be used simultaneously, separately or sequentially in anti-tumor therapy. Compounds of the invention, that can be used both in mono- or polychemotherapy, reach surprising results against tumors, thus avoiding the onset of dangerous side-effects, such as nephrotoxicity induced by cisplatinum, and increasing the long term survival rates.

Pharmaceutical compositions having antineoplastic activity

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Monza, Italy

Ennio Cavalletti