Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag

Egis Gyogyszergyar Zrt.

Enikó Molnár

Márta Porcs-Makkay

Gyula Simig

Tibor Mezei

Balazs Volk

Balázs Volk

Gyula Lukács

Jozsef Barkoczy

Tibor Szabo

József Barkóczy

Ferenc Lorant Bartha

Laszlo Pongo

Kálmán Nagy

Gyula Lukacs

László Szlávik

Adrienn Keszthelyi

Gyorgy Krasznai

Györgyi Vereczkeyné Donáth

Maria Tothne Lauritz

Gyorgy Ruzsics

Eva Szabo

János Szulágyi

Gyuláné Körtvélyessy

Jozsef Debreczeni

Janos Petho

Norbert Mesterházy

Éva Pécsi

Mária Vajjon

Valéria Hofmanné Fekete

György Krasznai

Judit Halasz

Marta Porcs-makkay

Jószef Barkóczy

The present invention relates a new process for the preparation of ozanimod of the formula and acid addition salts, via new intermediates and a new polimop form of ozanimod base.

Process for the production of ozanimod

The present invention is related to methods for the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S,6E)-dihydroxy-hept-6-enoic acid, intermediates thereof and methods for producing said intermediates.

Method for preparing rosuvastatin salts

The invention relates to a process for the preparation of cyclopropyl benzyl ketone compounds of formula (II) wherein Rrepresents fluorine or chlorine atom or Calkoxy group, by the reaction of a Grignard reagent, obtained from the reaction of compound of formula (V), wherein X represents chlorine or fluorine atom, with the compound of formula (IV), wherein Rrepresents Calkyl group, having a straight or branched chain. The process can be applied preferably on industrial scale. Compound of formula (II), wherein R represents a fluorine atom in position 2 is an intermediate of the preparation process of prasugrel, which is a platelet inhibitor used in the therapy. 

Process for the preparation of pharmaceutical intermediates

The invention provides a process for the preparation of high purity meloxicam of the Formula (II). The meloxicam raw product is reacted with the solution of potassium hydroxide or potassium carbonate, whereby high purity meloxicam potassium sait monohydrate is produced. Said sait is subsequently treated with mineral or organic acid to yield high-purity meloxicam.

Process for preparation of high-purity meloxicam and meloxicam potassium salt

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Erd, Hungary

Enikó Molnár